CAS NO:50-03-3 Hydrocortisone acetate

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1 Kilogram	Negotiable

1 Kilogram

Negotiable

Min.Order :1 Kilogram
Purity: 99%
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Keywords

Hydrocortisone acetate 50-03-3 C23H32O6

Quick Details

Appearance:white powder
Application:50-03-3
PackAge:As requested
ProductionCapacity:300|Kilogram|Day
Storage:0-6°C
Transportation:By air or by sea

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Hydrocortisone acetate Basic information

Adrenocorticotropic hormone drugs Indications Contraindications Adverse Reactions Precautions Chemical Property Uses Production methods

Product Name:	Hydrocortisone acetate
Synonyms:	(11beta)-21-(Acetoxy)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione;11,17-Dihydroxy-3,20-dioxopregn-4-en-21-yl acetate;11-beta,17-alpha-dihydroxy-21-acetoxypregesterone;11beta17alpha-Dihydroxy-21-acetoxypregesterone;17-alpha-hydrocorticosterone21-acetate;17alpha-Hydrocorticosterone-21-acetate;17-dihydroxy-20-dion(11-beta)-pregn-4-ene-21-(acetoxy)-11;17-dihydroxy-20-dion(11beta)-pregn-4-ene-21-(acetyloxy)-11
CAS:	50-03-3
MF:	C23H32O6
MW:	404.5
EINECS:	200-004-4
Product Categories:	Biochemistry;Hydroxyketosteroids;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;Veterinaries;Steroid and Hormone;Hormone Drugs;Adrenal cortical hormone drugs;API
Mol File:	50-03-3.mol

Hydrocortisone acetate Chemical Properties

Melting point	223 °C (dec.)(lit.)
Fp	223°C
storage temp.	0-6°C
Decomposition	223 ºC
Merck	14,4787
BRN	2066841
Stability:	Stable, but may be light or moisture sensitive. Incompatible with strong oxidizing agents.
CAS DataBase Reference	50-03-3(CAS DataBase Reference)
NIST Chemistry Reference	Hydrocortisone acetate(50-03-3)

Safety Information

Hazard Codes	Xn,T
Risk Statements	63-10-45
Safety Statements	36/37-45-53
WGK Germany	3
RTECS	GM8960000

Hydrocortisone acetate Usage And Synthesis

Adrenocorticotropic hormone drugs	Hydrocortisone acetate is an adrenal hormone drugs, white crystalline powder, odorless, bitter taste. The melting point is 216 ~ 222 ℃, right optical. Slightly soluble in ethanol, ether, chloroform, acetone, insoluble in water. It was synthesized by In 17α- hydroxy progesterone. Hydrocortisone acetate has important physiological activities such as anti-inflammatory, anti-viral, anti-allergic, anti-shock, reducing inflammatory exudation effect, commonly used in clinical adrenal insufficiency and autoimmune diseases. Preparations are injection, tablets, ointments and eye drops. Adding a small amount of hydrocortisone acetate in some cosmetics cortisol can increase the efficacy of anti-allergy and improve the degree of whitening of the skin, but long-term using of such substances can cause the skin produce hormone-dependent disease. Our cosmetics cosmetics specifications prescribedthathormone substances can not be added.
Indications	For allergic, non-infectious skin diseases and a number of proliferative skin disorders. Such as dermatitis, eczema, neurodermatitis, seborrheic dermatitis and itching psychosis. Figure 1 the chemical structure formula of tetra-fluoroethane.
Contraindications	1. This medicine and matrix components allergy and allergic to other glucocorticoids are prohibited. 2. The primary bacterial, fungal and viral infectious skin diseases such as disabledare prohibited. The above information is edited by the chemicalbook of KuiMing.
Adverse Reactions	Long-term using can cause local skin atrophy, telangiectasia, pigmentation, folliculitis, perioral dermatitis and secondary infection.
Precautions	1. Not long-term, large-scale use. 2. The coated parts such as a burning sensation, itching, swelling, etc., should stop the medication.
Chemical Property	White or almost white crystalline powder, odorless. Mp218-221.5 ℃; 25D + 166 ° (dioxane) Specific rotation [α]; ethanol maximum absorption at 240nm wavelength. Insoluble in water, slightly soluble in ethanol (1: 230) and chloroform (1: 150), insoluble in ether.
Uses	Corticosteroid drugs, have anti-inflammatory, anti-allergic, anti-toxins, anti-shock effect.
Production methods	Hydrocortisone and acetic anhydride in pyridine esterification.
Chemical Properties	white powder
Usage	Glucocorticoid

Hydrocortisone acetate Preparation Products And Raw materials

Raw materials

Azabenzene-->Hydrocortisone-->Saponin

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