Dovitinib (TKI-258,...

Dovitinib (TKI-258, CHIR-258)
Dovitinib (TKI-258, CHIR-258)
Dovitinib (TKI-258, CHIR-258)

Dovitinib (TKI-258, CHIR-258)

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1 Kilogram

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Dovitinib (TKI-258, CHIR-258) 405169-16-6 C21H21FN6O

Quick Details

  • Appearance:powder
  • Application:405169-16-6
  • PackAge:as requested
  • ProductionCapacity:300|Kilogram|Month
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Dovitinib (TKI-258, CHIR-258) Basic information
Product Name: Dovitinib (TKI-258, CHIR-258)
Synonyms: 4-Amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one;4-amino-5-fluoro-3-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one;CHIR-258;Unii-I35H55G906;CHIR258 7.7G;TKI-258;4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one;CHIR-258(Dovitinib,TKI258)
CAS: 405169-16-6
MF: C21H21FN6O
MW: 392.44
EINECS:  
Product Categories: API intermediates;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors
Mol File: 405169-16-6.mol
Dovitinib (TKI-258, CHIR-258) Structure
 
Dovitinib (TKI-258, CHIR-258) Chemical Properties
density  1.386
 
Safety Information
MSDS Information
 
 
Dovitinib (TKI-258, CHIR-258) Usage And Synthesis
Usage Compound used in treating melanoma
Usage Dovitinib (TKI258, CHIR-258) is a multitargeted tyrosine kinase inhibitor of FLT3 and c-KIT with IC50 of 1 nM and 2 nM, respectively.
Usage Dovitinib (TKI258, CHIR258) is a novel multi-target inhibitor for Flt3, c-Kit, FGFR1/3, VEGFR1/2/3, PDGFRα/β with IC50 of 1 nM, 2 nM, 8 nM/9 nM and 10 nM/13 nM/8 nM, 210 nM/27 nM respectively.
 
Dovitinib (TKI-258, CHIR-258) Preparation Products And Raw materials
 

 

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