THIOSTREPTON

THIOSTREPTON
THIOSTREPTON
THIOSTREPTON

THIOSTREPTON

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1 Kilogram

Negotiable

  • Min.Order :1 Kilogram
  • Purity: 98%
  • Payment Terms : L/C,D/A,D/P,T/T,,MoneyGram,Other

Keywords

THIOSTREPTON 1393-48-2 C72H85N19O18S5

Quick Details

  • Appearance:powder
  • Application:1393-48-2
  • PackAge:as requested
  • ProductionCapacity:300|Kilogram|Month
  • Storage:store in cool, dry place
  • Transportation:by sea or by air

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THIOSTREPTON Chemical Properties
Melting point  248-257°C (dec.)
storage temp.  −20°C
Merck  13,9440
 
Safety Information
Hazard Codes  Xn
Risk Statements  22
Safety Statements  22-24/25
WGK Germany  3
RTECS  XN6300100
F  10-21
MSDS Information
Provider Language
SigmaAldrich English
 
THIOSTREPTON Usage And Synthesis
Chemical Properties Off-White Solid
Usage beta-adrenergic agonist
Usage Thiostrepton is a macrocyclic antibiotic incorporating thiazoles and other atypical amino acids. Patented in 1961, thiostrepton has been used as an antibiotic and acts by binding to ribosomes to prevent the binding of the EF-G elongation factor and GTP to the 50S ribosomal subunit. Thiostrepton is an inducer of tipA, a gene that controls the bacterial transcription regulators, TipAL and TipAS, that are central regulators in multidrug resistance. Thiostrepton is closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1.
Usage Thiostrepton is a macrocyclic antibiotic incorporating thiazoles and other atypical amino acids. Patented in 1961, thiostrepton has been used as an antibiotic and acts by binding to ribosomes to prevent the binding of the EF-G elongation factor and GTP to the 50S ribosomal subunit. Thiostrepton is an inducer of tipA, a gene that controls the bacterial transcription regulators, and TipAL and TipAS, that are central regulators in multidrug resistance. Thiostrepton is closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1.
Usage Natural antibiotic derived from Streptomyces.
Definition ChEBI: A heterodetic cyclic peptide, in which the cyclisation step involves a formal lactonisation between the carboxy group of a quinaldic acid-based residue and a secondary alcohol. An antibiotic that inhibits bacterial protein synthesis. Also acts as an antitu or agent.
 
THIOSTREPTON Preparation Products And Raw materials

 

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