221877-54-9 ZOTAROLIMUS

Min.Order / FOB Price:Get Latest Price

100 Kilogram	Negotiable

100 Kilogram

Negotiable

Min.Order :100 Kilogram
Purity: 99%
Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

Rapamycin Tetrazolyl Deoxy

Quick Details

Appearance:Pale Yellow Solid
Application:221877-54-9
PackAge:As your request
ProductionCapacity:300|Kilogram|Month
Storage:Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Transportation:by express or air or sea

Superiority:

Tech Data Relevant

1.Certificate Of Analysis (COA)

2..Material Safety Data Sheet (MSDS)

3.Technical Data Sheet(TDS)

4.Route of synthesis (ROS)

5.Nuclear Magnetic Resonance(NMR)

6.Method of Analysis(MOA)

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Details:

Product Name:	ZOTAROLIMUS
Synonyms:	ZOTAROLIMUS;(42S)-42-Deoxy-42-(1H-tetrazol-1-yl)rapamycin;A 179578;ABT 578;Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-;Unii-H4gxr80ize;ZotaroliMus, >90%;42-(1-Tetrazolyl)rapamycin
CAS:	221877-54-9
MF:	C52H79N5O12
MW:	966.219
EINECS:
Product Categories:	Intermediates & Fine Chemicals;Pharmaceuticals;Chiral Reagents;Heterocycles;Inhibitors
Mol File:	221877-54-9.mol

ZOTAROLIMUS Chemical Properties

Melting point	100-105°C
density	1.25
storage temp.	Hygroscopic, -20°C Freezer, Under Inert Atmosphere

Safety Information

MSDS Information

ZOTAROLIMUS Usage And Synthesis

Chemical Properties	Pale Yellow Solid
Usage	Zotarolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by preparation of the 42-triflate ester, followed by displacement with tetrazole and purification of the two isomeric products. This structural change affords a less bioavailable product, a preferred profile for some applications. Like all tacrolimus analogues, zotarolimus binds to a receptor protein (FKBP12). The complex then binds to preventing it from interacting with target proteins. Zotarolimus is extensively cited in the literature with over 200 citations.
Usage	Zotarolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by preparation of the 42-triflate ester, followed by displacement with tetrazole and purification of the two isomeric products. This structural change affords a less bioavailable product, a preferred profile for some applications. Like all tacrolimus analogues, zotarolimus binds to a receptor protein (FKBP12). The complex then binds to mTOR preventing it from interacting with target proteins. Zotarolimus is extensively cited in the literature with over 200 citations.
Usage	A tetrazole-containing Rapamycin analog as immunomodulator and useful in the treatment of restenosis and immune and autoimmune diseases.

ZOTAROLIMUS Preparation Products And Raw materials

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