N-[(2R)-1,4-dioxan-2-ylMethyl]-N-Methyl{[5-(1-Methyl-1H-pyrazol-4-yl)-2-oxo-7-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-14-yl]aMino}sulfonaMide C24H25N5O5S 917879-39-1
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Product information
Mk-2461 . Basic information |
Product Name: | Mk-2461 . |
Synonyms: | Mk-2461 .;N-[(2R)-1,4-dioxan-2-ylMethyl]-N-Methyl{[5-(1-Methyl-1H-pyrazol-4-yl)-2-oxo-7-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-14-yl]aMino}sulfonaMide;N-((2R)-1,4-Dioxan-2-ylmethyl)-N-methyl-N'-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]sulfamide;Mk-2461 . N-[(2R)-1,4-dioxan-2-ylMethyl]-N-Methyl{[5-(1-Methyl-1H-pyrazol-4-yl)-2-oxo-7-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-14-yl]aMino}sulfonaMide |
CAS: | 917879-39-1 |
MF: | C24H25N5O5S |
MW: | 495.557 |
EINECS: | |
Product Categories: | Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Tyrosine Kinase Inhibitors;Inhibitors |
Mol File: | 917879-39-1.mol |
Mk-2461 . Chemical Properties |
Safety Information |
Mk-2461 . Usage And Synthesis |
Usage | MK-2461 is a potent inhibitor of c-Met, Ron, Flt1/3, PDGFRβ, Mer and FGFR1/2/3 with IC50 of 2.5 nM, 7 nM, 10 nM/22 nM, 22 nM, 24 nM and 65 nM/39 nM/50 nM, respectively. |
Usage | MK-2461 is a novel ATP-competitive multitargeted kinase inhibitor that preferentially inhibits the activated c-Met receptor. MK-2461 is also a potent inhibitor of Ron, Flt1, Flt 3, PDGFRβ, and Mer receptors. Recent studies show that MK-2461 siginifciantly suppresses tumor growth of GTL-16 xenografts in mice and MK-2461 treatments effectively inhibit the growth of NIH3T3 tumors harboring c-Met single nucleotide mutants T3936C and T3997C. |
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