Dexamethasone

Dexamethasone
Dexamethasone
Dexamethasone

Dexamethasone

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1 Kilogram

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Dexamethasone 50-02-2 C22H29FO5

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  • Appearance:powder
  • Application:50-02-2
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  • ProductionCapacity:300|Kilogram|Month
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Dexamethasone Basic information
Anti-inflammatory glucocorticoid Side Effects Drug Reactions Uses
Product Name: Dexamethasone
Synonyms: 16alpha)-;16alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-(11bet;16alpha-methyl-9alpha-fluoro-1,4-pregnadiene-11beta,17alpha,21-triol-2,20-dione;16-alpha-methyl-9-alpha-fluoro-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,2;16-alpha-Methyl-9-alpha-fluoro-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,20-dione;16-alpha-methyl-9-alpha-fluoro-11-beta,17-alpha,21-trihydroxypregna-1,4-dien;16alpha-Methyl-9alpha-fluoro-11beta-17alpha-21-trihydroxypregna-1,4-diene-3,20-dione;16-alpha-methyl-9-alpha-fluoro-1-dehydrocortisol
CAS: 50-02-2
MF: C22H29FO5
MW: 392.46
EINECS: 200-003-9
Product Categories: Active Pharmaceutical Ingredients;Antitumors for Research and Experimental Use;Biochemistry;Hydroxyketosteroids;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;Isotope Labeled Compounds;Steroid and Hormone;Pharmaceutical intermediate;API;MAXIDEX;Hormone Drugs;Mainly used for anti-inflammatory and allergy
Mol File: 50-02-2.mol
Dexamethasone Structure
 
Dexamethasone Chemical Properties
Melting point  262-264 °C(lit.)
alpha  75 º (c=1, dioxane)
refractive index  76 ° (C=1, Dioxane)
storage temp.  2-8°C
solubility  ethanol: 1 mg/mL
form  powder
color  off-white
Water Solubility  10 mg/100 mL (25 ºC)
Merck  14,2943
BRN  2066651
Stability: Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, acid anhydrides, acid chlorides. May be light sensitive.
CAS DataBase Reference 50-02-2(CAS DataBase Reference)
NIST Chemistry Reference Prednisolone, 9alpha-fluoro-16alpha-methyl-(50-02-2)
EPA Substance Registry System Pregna-1,4-diene- 3,20-dione, 9-fluoro-11,17,21-trihydroxy- 16-methyl-, (11.beta.,16.alpha.)-(50-02-2)
 
Safety Information
Hazard Codes  Xi,Xn,T,F
Risk Statements  43-40-36/37/38-20/21/22-42/43-39/23/24/25-23/24/25-11
Safety Statements  36/37-45-36-26-22-16
WGK Germany  2
RTECS  TU3980000
Hazardous Substances Data 50-02-2(Hazardous Substances Data)
MSDS Information
 
Dexamethasone Usage And Synthesis
Anti-inflammatory glucocorticoid Dexamethasone is used to treat inflammatory and autoimmune conditions such as rheumatoid arthritis and bronchospasm. It is useful to study apoptosis, cell signaling pathways and gene expression. It is associated with marbofloxacin and clotrimazole and finds application in veterinary medicine to treat difficult ear infections in dogs. It is also used to treat horses with swelling of of distal limbs and general bruising in combination with trichlormethiazide. It is also an anti-inflammatory glucocorticoid.
Side Effects Dexamethasone is a artificially synthetic glucocorticoid, belonging to a long-term glucocorticoid drugs. Glucocorticoids can promote the metabolism of the three major nutrients while preventing protein synthesis with long-term topical being able to causing more serious consequences. However, the adverse effects should be much smaller than oral medication. Common side effects of systemic corticosteroid include: 
It can cause stomach discomfort and increased sensitivity to stomach ulcers. 
It can Increase the appetite and results in a significant increase in body weight.
Potential patients with diabetes: glucose intolerance in patients with aggravating existing diabetes.
It can cause mental illness including personality changes, irritability, agitation, and mania.
It can be used for the long-term treatment of osteoporosis: pathological fractures (such as hip).
It can cause elevated liver enzymes, fatty liver degeneration (usually reversible).
For patients of nephrotic syndrome, applying long-term high-dose medication is likely to cause large side effects such as gastrointestinal ulcers and avascular necrosis. For treatment of nephrotic syndrome, it is better to apply prednisone acetate tablets.
Dexamethasone can be used for the treatment of high altitude cerebral edema and pulmonary edema. Upon climbing expeditions, people can apply it to alleviate altitude sickness.
Combination with marbofloxacin and clotrimazole, etc. can be used for treating the ear infection and allergies of a dog or a bird.
The above information is edited by the chemicalbook of Dai Xiongfeng.
Drug Reactions Dexamethasone is a corticosteroid known as a glucocorticoid. Corticosteroids are meant to resemble a naturally occurring hormone produced in the adrenal cortex, cortisol. Corticosteroids act on the immune system by blocking the production of substances that trigger inflammatory and immune responses.
Dexamethasone may react with these drugs:
Amphotericin
Aspirin
Cyclophosphamide
Cyclosporine
Digoxin
Daunorubicin HCl
Doxorubicin HCl
Insulin
Mitotane
Phenobarbital
Phenytoin sodium
Rifampin
Rimadyl
Uses It is mainly used for anti-inflammatory and anti-allergy purpose which is suitable for treating rheumatoid arthritis and other collagen diseases.
Chemical Properties White Crystalline Solid
Description Dexamethasone is an Anti-inflammatory glucocorticoid that is used to treat inflammatory and autoimmune conditions such as rheumatoid arthritis and bronchospasm. It is useful to study apoptosis, cell signaling pathways and gene expression. It is associated with marbofloxacin and clotrimazole and finds application in veterinary medicine to treat difficult ear infections in dogs. It is also used to treat horses with swelling of of distal limbs and general bruising in combination with trichlormethiazide.
Dexamethasone induces the production of phospholipase A2 inhibitory protein (lipocortin). It also inhibits induction of nitric oxide synthase (IC50=5 nM). Dexamethasone has been shown to cause reduction in cyclin A and Cdk2 activity, inhibition of G1/S transition in osteoblasts and inhibition of phosphorylation of Rb protein in vitro. Dexamethasone has been observed to induce apoptosis in human thymocytes and eosinophils, but inhibits apoptosis in neutrophils in vitro. Dexamethasone is an activator of IDO.
Dexamethasone Inhibits the expression of the inducible but not the constitutive nitric oxide synthase in vascular endothelial cells (IC = 5 nM). Enhances active cation transport in aortic smooth muscle cells by stimulating the Na+-K+ pump. Has anti-inflammatory and anti-rheumatic properties. Induces apoptosis in human thymocytes. In general, 500-1000 nM of dexamethasone is sufficient to induce apoptosis following a 6-hour incubation at 37°C.
Usage Dexamethasone is a glucocorticoid used as an anti-inflammatory agent. Dexamethasone regulates T cell survival, growth, and differentiation. Dexamethasone inhibits the induction of nitric oxide synthas e.
Usage A glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase
General Description Odorless white to off-white crystalline powder with a slightly bitter taste.
Air & Water Reactions Insoluble in water.
Reactivity Profile Dexamethasone may be sensitive to prolonged exposure to light. Dexamethasone is incompatible with strong oxidizers, strong acids, acid chlorides and acid anhydrides. Oxidation may occur with bases.
Fire Hazard Flash point data for Dexamethasone are not available; however, Dexamethasone is probably combustible.
Biological Activity Glucocorticoid; anti-inflammatory. Reduces levels of activated NF- κ B in immature dendritic cells (DCs) and inhibits differentiation into mature DCs.
 
Dexamethasone Preparation Products And Raw materials
Preparation Products BECLOMETHASONE

 

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