Aminopterin

Aminopterin
Aminopterin
Aminopterin

Aminopterin

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1 Kilogram

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  • Min.Order :1 Kilogram
  • Purity: 98%
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Keywords

Aminopterin 54-62-6 C19H20N8O5

Quick Details

  • Appearance:powder
  • Application:54-62-6
  • PackAge:as requested
  • ProductionCapacity:300|Kilogram|Month
  • Storage:store in cool, dry place
  • Transportation:by sea or by air

Superiority:

Aminopterin Basic information
Product Name: Aminopterin
Synonyms: 4-amino-4-deoxypteroylglutamate;4-amino-folicaci;4-aminofolicacid[qr];4-amino-pga[qr];4-aminopteroylglutamicacid[qr];4-diamino-6-pteridinyl)methyl)amino)benzoyl)-n-(p-(((l-glutamicaci;AGPA;ai3-26079[qr]
CAS: 54-62-6
MF: C19H20N8O5
MW: 440.41
EINECS: 200-209-9
Product Categories: Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Aromatics;Inhibitors;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File: 54-62-6.mol
Aminopterin Structure
 
Aminopterin Chemical Properties
Melting point  228-235 °C (dec.)
alpha  18 º (c=1% in 0.1N NaOH)
storage temp.  2-8°C
solubility  2 M NaOH: 50 mg/mL
form  powder
color  yellow
Merck  13,471
CAS DataBase Reference 54-62-6(CAS DataBase Reference)
EPA Substance Registry System L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl) methyl]amino]benzoyl]-(54-62-6)
 
Safety Information
Hazard Codes  T+
Risk Statements  61-28-63-26/27/28
Safety Statements  53-28-36/37-45-36/37/39-22
RIDADR  UN 2811 6.1/PG 1
WGK Germany  3
RTECS  MA1050000
F  8-10-23
HazardClass  6.1(a)
PackingGroup  I
Hazardous Substances Data 54-62-6(Hazardous Substances Data)
 
Aminopterin Usage And Synthesis
Chemical Properties Dark Yellow Solid
Usage A folic acid antagonist. Its actively transported into cells by thefolate transporter. In the cell, its converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase, that, in turn, binds to dihydrofolate reductase and inhibits its activity.
Usage antineoplastic, antirheumatic, folic acid antagonist
General Description Clusters of yellow needles. Used as a rodenticide, medicine and rodenticide. Not registered as a rodenticide in the U.S.
Health Hazard An antimetabolite; antagonizes the utilization of folic acid by the body. Highly toxic by ingestion.
 
Aminopterin Preparation Products And Raw materials

 

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