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high purity Tacrolimus Tacrolimus for sale Tacrolimus in China
High purity Tacrolimus 109581-93-3 for sale in China
ThetherapeuticeffectofTacrolimusisinvestigatedonprogressionandperpetuationofcolitisbyadministeringTacrolimustoDextransulfatesodium(DSS)treatedmicefromDays10to16orto23.AtDays17and24,colonlengthissignificantlyshortened,andcolonweightissignificantlyhigherinDSStreatedcontrolanimalsthaninnormalanimals.Inaddition,colonweightperunitlengthinthecontrolgroupismorethantwicethatinthenormalgroup.Whileboth7and14dtreatmentwithTacrolimussignificantlysuppressesincreasesincolonweightperunitlengthinDSStreatedanimalscomparedwiththecontrolgroup,thistreatmentdoesnotactuallyrestorethecolonshortening.Inaddition,thisinhibitoryeffectofTacrolimusonincreasesincolonweightperunitlengthismorepronouncedwith14-dthan7-dtreatment,asshownbytheinhibitorypercentages(59%vs.28%).
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