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Tacrolimus (also known as FK-506 or tacrolimus, trade names Prograf, Advagraf, Protopic) is an immunosuppressive drug, mainly used to reduce the risk of organ rejection after allogeneic organ transplantation.
It does this by inhibiting the production of interleukin 2, which is a molecule that promotes the development and proliferation of T cells and is essential for the body's learning (or adaptive) immune response.
Tacrolimus is also used to treat other T cell-mediated diseases, such as eczema (applied on the skin with ointment), severe drug-resistant uveitis after bone marrow transplantation, sudden onset of minimal change disease, Kimura disease, skin
Disease leukoplakia.
Chemically, it is a 23-membered macrolide, which was discovered in 1987 from the fermentation broth of a Japanese soil sample containing the bacteria Streptomyces tsukubaensis.
Tacrolimus is used for:
Prevent organ rejection in some patients after liver, kidney or heart transplantation.
It can be used with other drugs.
It can also be used for other conditions determined by your doctor.
Tacrolimus is an immunosuppressant.
It prevents the action of certain blood cells (such as T lymphocytes), which can cause the body to reject the transplanted organ.
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