CasNo.109581-93-3,Factory supply Tacrolimus 109581-93-3 exporter,TACROLIMUS(109581-93-3) Suppliers

1 Gram	Negotiable

Min.Order :1 Gram
Purity: 98.5%min

Keywords

Supply Tacrolimus Tacrolimus exporter Tacrolimus factory

Quick Details

Appearance:White or almost white crystalline powder
Application:104987-11-3,109581-93-3,API
PackAge:As requirement
ProductionCapacity:5|Kilogram|Month
Storage:As normal
Transportation:AS NORMAL

Superiority:

Factory supply Tacrolimus 109581-93-3 exporter

The mechanism of action of tacrolimus in atopic dermatitis is not known. While the following have been observed, the clinical significance of these observations in atopic dermatitis is not known. It has been demonstrated that tacrolimus inhibits T-lymphocyte activation by first binding to an intracellular protein, FKBP-12. A complex of tacrolimus-FKBP-12, calcium, calmodulin, and calcineurin is then formed and the phosphatase activity of calcineurin is inhibited. This prevents the dephosphorylation and translocation of nuclear factor of activated T-cells (NF-AT), a nuclear component thought to initiate gene transcription for the formation of lymphokines. Tacrolimus also inhibits the transcription for genes which encode IL-3, IL-4, IL-5, GM-CSF, and TNF-, all of which are involved in the early stages of T-cell activation. Additionally, tacrolimus has been shown to inhibit the release of pre-formed mediators from skin mast cells and basophils, and to downregulate the expression of FceRI on Langerhans cells.

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FAQ:

Q1:Will you supply samples for testing

A: samples for the quality evaluation for most products, but customers need to undertake the shipping fee for delivery the samples to your door.

Q2:What's your MOQ

A: For the high value product, our MOQ starts from 10g,100g and 1kg.

Q3:Which kind of payment terms do you accept

A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by bitcoin,usdt,xmr,west union

Q4:How about your delivery time

A: Generally, it will take 3 to 5 days after receiving your advance payment.

Q5:How do you treat quality complaint

A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.