CAS NO:111470-99-6 ...

CAS NO:111470-99-6 Amlodipine besilate
CAS NO:111470-99-6 Amlodipine besilate
CAS NO:111470-99-6 Amlodipine besilate

CAS NO:111470-99-6 Amlodipine besilate

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Keywords

Amlodipine besilate 111470-99-6 C26H31ClN2O8S

Quick Details

  • Appearance:powder
  • Application:111470-99-6
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  • ProductionCapacity:300|Kilogram|Month
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Amlodipine besilate Basic information
Product Name: Amlodipine besilate
Synonyms: 2-[(2-AMINOETHOXY)-METHYL]-4-(2-CHLOROPHENYL)-1,4-DIHYDRO-6-METHYL-3,5-PYRIDINEDICARBOXYLIC ACID 3-ETHYL 5-METHYL ESTER BENZENE SULFONATE;2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine benzenesulfonate;AMLODIPINE BENZENESULFONATE;AMLODIPINE BESILATE;AMLODIPINE BESYLATE;NORVASC;3,5-pyridinedicarboxylicacid,2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,;4-dihydro-6-methyl-,3-ethyl-5-methylester,monobenzenesulfonate
CAS: 111470-99-6
MF: C26H31ClN2O8S
MW: 567.05
EINECS:  
Product Categories: Active Pharmaceutical Ingredients;Dihydropyridine Class Chemicals;Intermediates & Fine Chemicals;Pharmaceuticals;Amlodipine;Aromatics;Dihydropyridine;Heterocycles;BENICAR;AZD929;Fine Chemical
Mol File: 111470-99-6.mol
Amlodipine besilate Structure
 
Amlodipine besilate Chemical Properties
Melting point  199-201°C
storage temp.  Store at RT
solubility  DMSO: 20 mg/mL
form  solid
color  white
CAS DataBase Reference 111470-99-6(CAS DataBase Reference)
 
Safety Information
Hazard Codes  Xn
Risk Statements  22-36/37/38-20/21/22
Safety Statements  26-36
WGK Germany  3
RTECS  US7967700
Hazardous Substances Data 111470-99-6(Hazardous Substances Data)
MSDS Information
Provider Language
SigmaAldrich English
 
Amlodipine besilate Usage And Synthesis
Chemical Properties White Crystalline Solid
Usage A dihydropyridine calcium channel blocker. Used as an antianginal and antihypertensive
Usage Angiotensin II inhibitor prodrug, antihypertensive
Usage Amlodipine besylate is a L-type calcium channel blocker which may be used for the treatment of angina pectoris and hypertension. Amlodipine also inhibits growth of human epidermoid carcinoma A431 cells and has antireproductive effects in male rats.
Definition ChEBI: The benzenesulfonate salt of amlodipine.
Biological Activity L-type calcium channel blocker that displays antihypertensive properties. Inhibits Ca 2+ -induced contractions in depolarized rat aorta (IC 50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC 50 = 25 μ M).
 
Amlodipine besilate Preparation Products And Raw materials

 

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