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Peptides Pharmaceutical Intermediate Chemical
This is Allen from Zhengzhou Filter Biotechnology Co.,Ltd.We are the professional supplier of peptide products in China over 10 years. we have Professional Lab to confirm the Quality and Serive for all clients in long-term run cooperation.
Our Company as a Pharmaceutical Raw Material Manufacturer specialize in R&D the New Drugs and Producing the Generic Medicine:
Amino Acids&Vitamins
Pharmaceutical Polypeptide,
Comestic Polypeptide,
Veterinary Peptide and
Pharmaceutical APIs.
Due to of the high quality and good service, They have been exported more than 30 countries.
Sincerely hope to have a chance to cooperate with you
Description
Product Name:
Dynorphin A (1-13) | |
Synonyms: | TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS;TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS 5ACOH 6H2O;TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS PORCINE;YGGFLRRIRPKLK;L-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS;DYNORPHIN A PORCINE FRAGMENT 1-13;DYNORPHIN A(HUMAN, 1-13);DYNORPHIN A (HUMAN, 1-13) (PORCINE, RAT, BOVINE) |
CAS: | 72957-38-1 |
MF: | C75H126N24O15 |
MW: | 1603.95 |
EINECS: | ----- |
Product Categories: | DynorphinsPeptides for Cell Biology;Dynorphins;Neuropeptides;Opioid Peptides;Opioid receptor and opioid-like receptor;peptide |
Purity: | 99%, 98% |
Dynorphin A(1–13), a tridecapeptide of the endogenous opioid peptides, has modest effects in reducing mild opiate withdrawal in humans. Previous studies revealed that dynorphin also potentiates the analgesic effect of morphine in morphine-tolerant rats and mice. The therapeutic potential of dynorphin A(1–13) is limited due to extensive metabolism by human metabolic enzymes resulting in an in vivo half-life of less than one minute. Chemical modifications of dynorphin A(1–13), such as N-methylation of Tyr1 and amidation of the C-terminus have been shown to be effective in protecting against the proteolytic enzymes in human plasma. This article is a general review of the metabolism of dynorphin A(1–13) in human plasma and CSF.
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