Pharma grade 99% Pharmaceutical Powder Losartan potassium for Antihypertensive

Min.Order / FOB Price:Get Latest Price

10 Gram	FOB Price:USD 0.5000 -1.0000

10 Gram

FOB Price:USD 0.5000 -1.0000

Min.Order :10 Gram
Purity: 99%
Payment Terms : L/C,D/A,D/P,T/T,,MoneyGram,Other

Keywords

Losartan potassium salt Pharmaceutical material Anti hypertensive

Quick Details

Appearance:White to Off-White Crystalline Powder
Application:health & medicine, chemical, pharmaceutical
PackAge:Discreet packing ways as your requirement, 100% go through
ProductionCapacity:1000|Kilogram|Month
Storage:Store in cool and dry area and keep away from direct sunlight
Transportation:As your required

Superiority:

1. Quality assurance

With our years of experience, advanced technology and continuous research, our quality is to fully meet the needs of the market to meet the requirements of customers, many customers use our products, we believe that the product is very good. Whether it is a powder, or liquid, yes, we all know, our liquid better.

2. Safe transportation

Our mode of transport is taken according to each country's situation is different transportation, while our packaging, according to the latest customs situation, constantly updated, improved our packaging, we guarantee that you receive it within 3-5 to your product.

3. The product diversity

Our products are powders and liquids, yes, brothers, the effect of the liquid is very good, but many people do not use liquid, so you are very lucky, you buy our powder, we can tell you the method of making the liquid If you buy a liquid, we will tell you how to filter. We absolutely guarantee that you can very safely use our products

4. High quality service

Our goods packing will not contain any hormone information and can be sent out from different areas of china. At present,the goods customs clearance rate we send to United states and Europe is 99%, As for Canada, Brazil of quite high buckle close rate area, we also have a new way to get through the customs. We also have completely re-send policy to some areas.

Details:

Pharmaceutical material Losartan potassium for Antihypertensive

Synonyms	Losartan potassium salt
CAS NO	124750-99-8
MF	C22H23ClKN6O
MW	462.01
Purity	99%
Appearance	White to Off-White Crystalline Powder
Certification	GMP,ISO 9001,USP
Standard	Enterprise standard
Usage	A nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.
Packing	Discreet packing ways as your requirement, 100% go through
Storage	Store in cool and dry area and keep away from direct sunlight

Description:

1. Losartan potassium,Losartan is well absorbed following oral administration and undergoes significant first-pass metabolism to produce the 5-carboxylic acid metabolite, designated as EXP3174. About 14% of an oral dosage is converted to this metabolite, which is long-acting (6 to 8 hr) and a noncompetitive antagonist at the AT1 receptor, contributing to the pharmacological effects of losartan. EXP3174 is 10-40 times more potent in blocking AT1 receptors than losartan. Losartan's bioavailability is about 32%.

2. Losartan potassium,Metabolism is primarily by cytochrome P450 isoenzymes CYP2C9 and CYP3A4. Peak plasma concentrations of losartan and EXP3174 occur about one hour and three to four hours, respectively, after an oral dose. Both losartan and EXP3174 are more than 98% bound to plasma proteins. Losartan is excreted in the urine, and in the feces via bile, as unchanged drug and metabolites. About 4% of an oral dose is excreted unchanged in urine, and about 6% is excreted in urine as the active metabolite. The terminal elimination half lives of losartan and EXP3174 are about 1.5 to 2.5 hours and 3 to 9 hours, respectively.

Specification:

Items of analysis	Specification	Results
Characters	White or off white crystalline powder	off white powder
Solubility	Free soluble in water and methanol, very slightly soluble in chloroform	Conforms
Infraed absorption	Must similar to reference standard	Conforms
Ultraviolet absorption	Must similar to reference standard	Conforms
Test for potassium	Must be positive	positive
Water	≤0.5%	0.20%
Heavy metals	≤10ppm	<10ppm
Single impurity	≤0.2%	0.07%
Total impurity	≤0.5%	0.12%
Isopropyl alcohol	≤2000ppm	234ppm
Assay	98.5-101%	99.8%
Conclusion	Qualified

Usage:

1.A nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.

2.antihypertensive, AT1 angiotensin II antagonist

3.Coronary vasodilator used in the diagnosis of coronary heart disease (adenosine A2A agonist).

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