Aztreonam 98% supplier in China

Details:

1. Introduction of Aztreonam-

Aztreonam-, with the cas number of 78110-38-0, is a synthetic monocyclic beta-lactam antibiotic (a monobactam). The IUPAC Name is 2-[(Z)-[1-(2-amino-1,3-thiazol-4-yl)-2-[[(2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]amino]-2-oxoethylidene]amino]oxy-2-methylpropanoic acid. In addition, the empirical formula is C₁₃H₁₇N₅O₈S₂ and the molecular weight is 435.4328.

2. Basic Information of Aztreonam-

Aztreonam (CAS NO.78110-38-0) is used to treat infections which caused by sensitive gram-negative bacteria . Aztreonam (CAS NO.78110-38-0) is a toxic material, burning will produce toxic fumes of nitrogen oxides and sulfur oxides, Besides should be stored and transported in low-temperature, drying environment. separately with oxidizing agents. Fire extinguishing agents water, carbon dioxide, dry powder, foam would be used if emergency.

1) Properties

Molar Refractivity: 95.58 cm³
Molar Volume: 236.9 cm³
Surface Tension: 84.1 dyne/cm
Index of Refraction: 1.74
Storage temp: 0-5°C
Melting Point: 227°C
Form: solid
Appearance: White to off-white crystals
Density: 1.83 g/cm³
Product Categories: Active Pharmaceutical Ingredients; Antibacterial; Chiral Reagents; Intermediates & Fine Chemicals; Pharmaceuticals

2) Toxicity

3) Mechanism of action

Aztreonam is similar in action to penicillin. It inhibits mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking. It has a very high affinity for penicillin-binding protein 3 (PBP-3) and mild affinity for PBP-1a. Aztreonam binds the penicillin-binding proteins of gram-positive and anaerobic bacteria very poorly and is largely ineffective against them. Aztreonam is bactericidal but less so than some of the cephalosporins.

4) Safety Profile
Moderately toxic by several routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and SOx.
Hazard Codes Xn
Risk Statements 20/21/22-36/37/38
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements 22-24/25-36-26
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
S36:Wear suitable protective clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 2
RTECS: UA2451400