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64-86-8 exporter Competitive price 64-86-8 Top quality 64-86-8
Competitive price 64-86-8 /Top quality 64-86-8 exporter /Colchicine
Description
Colchicine, a tubulin Inhibitor, has been shown to block polymerization of microtubules by binding to tubulin. Studies indicate that this reagent also causes apoptosis of cells by acting on tissue plasminogen activators (tPA) and disrupting the cytoskeleton of cells. Exposure of cells to Colchicine has also been reported to result in alterations of Ca2+ concentrations in cells which may also result in apoptosis.
Product Name:Colchicine
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Competitive price 64-86-8 /Top quality 64-86-8 exporter /Colchicine
Product Detail
Name: Acetamide,N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-
CAS No.: 64-86-8
Formula: C22H25NO6
Molecular Weight: 399.44
Synonyms: Acetamide,N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S)-;Colchicine (8CI);(-)-Colchicine;(S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide;Colchineos;Colchisol;Colcin;Colsaloid;Condylon;NSC 757;
EINECS: 200-598-5
Density: 1.25 g/cm3
Melting Point: 150-160 °C (dec.)(lit.)
Boiling Point: 726 °C at 760 mmHg
Flash Point: 392.9 °C
Solubility: 45 g/L (20 °C) in water
Appearance: Yellow solid
Using
Anti-gout and antineoplastic agents, for the treatment of acute gout and tumor
Colchicine, a tubulin Inhibitor, has been shown to block polymerization of microtubules by binding to tubulin. Studies indicate
that this reagent also causes apoptosis of cells by acting on tissue plasminogen activators (tPA) and disrupting the
cytoskeleton of cells. Exposure of cells to Colchicine has also been reported to result in alterations of Ca2+ concentrations in
cells which may also result in apoptosis.
Main Function
1.Colchicine has the function of anti-gout, anti-tumor, inhibiting the mitotic cell stopping in M phase.
2.Colchicine has the significant effects on breast cancer, cervical cancer, esophageal cancer, lung cancer,gastric
cancer and chronic myelogenous leukemia.
3.Colchicine also can be used for acute gout, anti-inflammatory analgesic.
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