Details:

Actinomycin D Basic information

Product Name:	Actinomycin D
Synonyms:	1-ethanediyl)imino(2-(1-methylethyl)-carbonylimino(2-(1-hydroxyethyl)-1-oxo-;1-oxo-2,1-ethanediyl)-1,2-pyrrolidinediylcarbonyl(methylimino)(1-oxo-2,1-ethan;3h-phenoxazine-1,9-dicarboxamide,2-amino-n,n’-bis(hexadecahydro-2,5,9-trimethy;6-dimethyl-3-oxo-xatetra-azacyclohexadecin-10-yl)-;actd;actinomycin-(thre-val-pro-sar-meval);actinomycin11cosmegen;actinomycin7
CAS:	50-76-0
MF:	C62 H86 N12 O16
MW:	1255.44
EINECS:	232-485-1
Product Categories:	Antibiotics;Antibiotic Explorer;Intermediates & Fine Chemicals;Peptides;Pharmaceuticals;Caspases/Apoptosis;COSMEGEN;antibiotic
Mol File:	50-76-0.mol

Actinomycin D Chemical Properties

Melting point	251-253 °C
storage temp.	2-8°C
solubility	ethanol, DMSO: Stable in aqueous solutions at 2-8 °C.soluble
form	powder
color	red, powder
Water Solubility	SOLUBLE
Merck	13,2828
Stability:	Stable, but light sensitive, especially in dilute solution. Incompatible with strong acids, strong bases, strong oxidizing agents. Combustible.
CAS DataBase Reference	50-76-0(CAS DataBase Reference)
EPA Substance Registry System	Actinomycin D(50-76-0)

Safety Information

Hazard Codes	T+
Risk Statements	28-61-40-45-26/27/28
Safety Statements	53-36/37/39-45-1-36/37-28-22
RIDADR	UN 3462 6.1/PG 2
WGK Germany	3
RTECS	AU1575000
F	8-10-21
HazardClass	6.1(a)
PackingGroup	II
HS Code	29419000
Hazardous Substances Data	50-76-0(Hazardous Substances Data)

MSDS Information

Provider	Language
Actinomycin D	English
SigmaAldrich	English

Actinomycin D Usage And Synthesis

Chemical Properties	red crystalline powder
Usage	An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis. Potent antitumor agent.
Usage	antineoplastic, intercalating agent
Usage	Actinomycin D is the most studied member of a family of unique bicyclic depsipeptides produced by several Streptomyces species. The depsipeptides are linked by a heterocyclic benzoxazone "anchor" that gives the metabolites a highly distinctive red/orange colour. Actinomycin D exhibits potent antibiotic and antitumour activity via DNA intercalation leading to the inhibition of nucleic acid synthesis. Tumour cell death has been demonstrated to occur by apoptosis.
Usage	Actinomycin D is the most studied member of a family of unique bicyclic depsipeptides produced by several Streptomyces species. The depsipeptides are linked by a heterocyclic benzoxazone "anchor" that gives the metabolites a highly distinctive red/orange colour. Actinomycin D exhibits potent antibiotic and antitumor activity via DNA intercalation leading to the inhibition of nucleic acid synthesis. Tumor cell death has been demonstrated to occur by apoptosis.
Usage	Antibiotic substance belonging to the actinomycin complex, produced by several Streptomyces spp. Antineoplastic
General Description	Bright red rhomboid prisms or red powder.
Air & Water Reactions	Water soluble.
Reactivity Profile	Actinomycin D can react with strong oxidizing agents, strong acids and strong bases.
Fire Hazard	Flash point data for Actinomycin D are not available. Actinomycin D is probably combustible.
Biological Activity	Anti-neoplastic antibiotic. Inhibits RNA polymerase and is a potent inducer of apoptosis.

Actinomycin D Preparation Products And Raw materials

Raw materials

Aluminum oxide -->streptomyces avermifilis-->Sepia (dye)

Company Information

Henan Sunlake Enterprise Corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion. The com[any was established in june. 1998, until now having more than 18 years experience in manufacturing & exporting chemical raw material .

Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others. These products have been being well exported to europe, southeast Asia, the Middle East ,Africa, South America and some other countries and areas.

We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you better with our high - quality products and professional team. We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional supplier in international market.

We welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!