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Milrinone 3-CYANO-6-METHYL-5-(4-PYRIDYL)-2-PYRIDONE 78415-72-2
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Chemistry
Molecular Formula: C12H9N3O
Molecular Weight: 211.22
EINECS: 278-903-6
Index of Refraction: 1.622
Molar Refractivity: 57.76 cm3
Molar Volume: 164 cm3
Surface Tension: 60.2 dyne/cm
Density: 1.28 g/cm3
Flash Point: 225.2 °C
Enthalpy of Vaporization: 70.72 kJ/mol
Boiling Point: 448.7 °C at 760 mmHg
Vapour Pressure: 3.04E-08 mmHg at 25 °C
Storage tempreture: 2-8 °C
Solubility: DMSO: >10 mg/mL
Appearance: Off-white solid
Structure of Milrinone (CAS NO.78415-72-2):
IUPAC Name: 6-Methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile
Canonical SMILES: CC1=C(C=C(C(=O)N1)C#N)C2=CC=NC=C2
InChI: InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
InChIKey: PZRHRDRVRGEVNW-UHFFFAOYSA-N
Product Category of Milrinone (CAS NO.78415-72-2): Active Pharmaceutical Ingredients;API;Heterocycles;Intermediates & Fine Chemicals;Cyclic Nucleotide related
Uses
Milrinone (CAS NO.78415-72-2) is used in the management of heart failure only when conventional treatment with vasodilators and diuretics has proven insufficient.
Specification
Milrinone , its cas register number is 78415-72-2. It also can be called 1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile ; Milrinonum ; and (3,4'-Bipyridine)-5-carbonitrile, 1,6-dihydro-2-methyl-6-oxo- . It is a phosphodiesterase III inhibitor, and enhances relaxation of the left ventricle by increasing Ca2+-ATPase activity on the cardiac sarcoplasmic reticulum.
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