PLX 4032

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0 Gram	Negotiable

0 Gram

Negotiable

Min.Order :0 Gram
Purity: 99%
Payment Terms : T/T|Westem Union

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Appearance:
Application:Vemurafenib (INN, marketed as Zelboraf) is a B-Raf enzyme inhibitor.
PackAge:plastic and foil bag
ProductionCapacity:|/
Storage:Store at or below -20 ℃ in dry, clean place
Transportation:By courier, by air, by sea

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Vemurafenib has been shown to cause programmed cell death in melanoma cell lines. Vemurafenib interrupts the B-Raf/MEK step on the B-Raf/MEK/ERK pathw…

Details:

Vemurafenib has been shown to cause programmed cell death in melanoma cell lines. Vemurafenib interrupts the B-Raf/MEK step on the B-Raf/MEK/ERK pathway − if the B-Raf has the common V600E mutation.

Vemurafenib only works in melanoma patients whose cancer has a V600E BRAF mutation (that is, at amino acid position number 600 on the B-Raf protein, the normal valine is replaced by glutamic acid). About 60% of melanomas have this mutation. It also has efficacy against the rarer BRAF V600K mutation. Melanoma cells without these mutations are not inhibited by vemurafenib; the drug paradoxically stimulates normal BRAF and may promote tumor growth in such cases.

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