Cabozantinib

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0 Gram	Negotiable

0 Gram

Negotiable

Min.Order :0 Gram
Purity: 99%
Payment Terms : T/T|Westem Union

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Appearance:white powder
Application:XL184 (Cabozantinib) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret
PackAge:plastic and foil bag
ProductionCapacity:|/
Storage:Store at or below -20 ℃ in dry, clean place
Transportation:By courier, by air, by sea

Superiority:

Solubility (25°C) DMSO 117 mg/mL Water …

Details:

Solubility (25°C)	DMSO 117 mg/mL
	Water <1 mg/mL
	Ethanol <1 mg/mL

Storage	2 years-20°CPowder
	2 weeks4°Cin DMSO
	6 months-80°Cin DMSO

XL-184 also displays potent activity against c-Met, Ret, Kit, Flt-1, Flt-3, Flt-4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM, 11.3 nM, 6 nM, 14.3 nM and 7 nM, respectively. XL184 has weak inhibitory activity against RON and PDGFRβ with IC50 of 124 nM and 234 nM, respectivey, and has low activity against FGFR1 with IC50 of 5.294 μM. XL184 at low concentration (0.1-0.5 μM) is sufficient to induce marked inhibition of constitutive and inducible Met phosphorylation and its resultant downstream signaling in MPNST cells, and inhibit HGF-induced MPNST cell migration and invasion. XL184 also induces marked inhibition of Met and VEGFR2 phosphorylation in cytokine-stimulated human umbilical vein endothelial cells (HUVECs). Although XL-184 has no significant effect on MPNST cell growth at 0.1 μM, XL184 at 5-10 μM significantly inhibits the MPNST cell growth

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