High effective pharmaceutical powder Allopurinol for antigout

Details:

High effective pharmaceutical powder Allopurinol for antigout

Description:

Allopurinol is an aminoalcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Allopurinol darkens above 572° F, and at an indefinite high temperature, Allopurinol chars and decomposes. At 221° F, maximum stability occurs at pH 3.1- 3.4. Allopurinol decomposes in acidic and basic solutions.

Application:

Allopurinol inhibits the breakdown (catabolism) of the thiopurine drug mercaptopurine, and was specifically invented by Gertrude Elion to enhance the action of mercaptopurine in the treatment of acute lymphoblastic leukemia. However, no improvement in leukemia response was noted with mercaptopurine-allopurinol cotherapy, and this use of the drug was abandoned.

Allopurinol is used as an add-on drug for refractory epilepsy, because it is an adenosine agonist, which inhibits glutamine release from excitatory neurons, but does not change the plasma concentration of other epilepsy drugs.

Allopurinol was also commonly used to treat tumor lysis syndrome in chemotherapeutic treatments, as these regimens can rapidly produce severe acute hyperuricemia, although it has gradually been replaced by urate oxidase therapy.

Use:

1.Use of allopurinol and its metabolites do not xanthine, both inhibition of xanthine oxidase interest, and

thus make uric acid synthesis is blocked, reducing blood uric acid concentrations, reduce urate calm in the bones, joints and kidneys. Clinical for gout, gouty nephropathy. Pregnant women with caution; Some patients may rash, gastrointestinal reactions and liver damage and hematopoietic systems, such as elevated transaminases and leukopenia; 6 with anticancer drugs - mercaptopurine when combined, to 6 - mercaptopurine dose is reduced to a constant 1/4. More water, in order to facilitate uric acid excretion.

2.Use of anti-gout drugs. For primary or secondary increase in serum uric acid of various diseases, such as gout, acute or chronic leukemia.

3.Use of anti-gout drug, used to treat gout, gouty nephropathy