High quality Thiazolines API Intermediate Piperazine for antiseborrheic

Details:

High quality Thiazolines API Intermediate Piperazine for antiseborrheic

Description:

Piperazine is an important pharmaceutical intermediate, is mainly used for the production of anthelmintic piperazine phosphate, piperazine citrate and fluphenazine, strong pain, rifampicin, adipic acid piperazine, piperazine guanidine methyl tetracycline, quinoline piperazine phosphate, piperazine thiazole nitrate, enoxacin, hydroxyzine hydrochloride, trifluoperazine, diethylcarbamazine citrate, cinnarizine, flunarizine, decloxizine strong carbamazepine, prednisolone sodium phosphate, dexamethasone sodium phosphate, PPA, norfloxacin, ciprofloxacin, easy to cough piperazine, a piperazine Lee vancomycin, trimethoprim-triazine and other drugs. It is Also used for the production of surfactants products such as wetting agents, emulsifying agents,and dispersing agents ,and the production of plastic additives such as antioxidants, preservatives, stabilizers and rubber additives. It is derived from Dichloroethane by alcohol solution of ammonia.

Application:

Piperazine is a safe and effective anti-roundworm and pinworm medicine, China's "Veterinary Pharmacopoeia" collection contains as piperazine citrate and phosphoric acid piperazine, the product can make roundworm muscle paralysis, so insects body can not be attached to the host intestinal wall and excreted with the feces. Piperazine mechanism is that it is capable of blocking cholinergic receptors at the neuromuscular junction, thereby preventing excitatory effects transmission of nerve impulses and acetylcholine. No excitement before the worm paralysis phenomenon, it is more secure. After oral ,it is rapidly absorbed by the gastrointestinal tract, it is metabolized in the body part, the rest is excreted by the kidneys. Its various salts in solution have become piperazine hexahydrate, absorption and excretion are basically the same, but the rate of excretion is of large individual differences. It is Clinically used for intestinal ascariasis, incomplete intestinal obstruction due to roundworm or early biliary ascariasis , it is also used for pinworm infection. 

Uses:

It is mainly used for the production of anthelmintic piperazine phosphate, piperazine citrate.Piperazine hexahydrate is dissolved in ethanol, piperazine acetic acid is precipitated by adding glacial acetic acid stirring and cooling , it is used in the synthesis of steroids prednisolone sodium phosphate. Piperazine hexahydrate reacts with acetic anhydride to prepare intermediate acetyl piperazine of anthelmintic piperazine nitro thiazole.