DL-Pyroglutamic aci...

DL-Pyroglutamic acid DL-Pyroglutamic acid CAS 149-87-1
DL-Pyroglutamic acid DL-Pyroglutamic acid CAS 149-87-1

DL-Pyroglutamic acid DL-Pyroglutamic acid CAS 149-87-1

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DL-Pyroglutamic acid DL-Pyroglutamic acid supplier CAS 149-87-1

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  • Appearance:white crystalline powder
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Details:

149-87-1   DL-Pyroglutamic acid
 
Product Name: DL-Pyroglutamic acid
Synonyms: DL-Proline, 5-oxo-;(+/-)-2-PYRROLIDONE-5-CARBOXYLIC ACID;2-PYRROLIDONE-5-CARBOXYLIC ACID;(+/-)-2-PYRROLIDINONE-5-CARBOXYLIC ACID;5-OXO-DL-PROLINE;DL-A-PYROGLUTAMIC ACID;DL-GLUTAMIC ACID LACTAM;DL-PYROGLUTAMIC ACID
CAS: 149-87-1
MF: C5H7NO3
MW: 129.11
EINECS: 205-748-3 
Appearance & Physical State: white powder
Density: 1.38 g/cm3
Melting Point: 180-185ºC
Boiling Point: 453.1ºC at 760 mmHg
Flash Point: 227.8ºC
Refractive Index: 1.511
Stability: Stable under normal temperatures and pressures.
Storage Condition: Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed.
Vapor Pressure: 1.79E-09mmHg at 25°C
 
 
 
Pyroglutamic acid (also known as PCA, 5-oxoproline, pidolic acid, or pyroglutamate for its basic form) is an uncommon and little studied amino acid derivative in which the free amino group of glutamic acid or glutamine cyclizes to form a lactam. It is a metabolite in the glutathione cycle that is converted to glutamate by 5-oxoprolinase. Pyroglutamate is found in many proteins including bacteriorhodopsin. N-terminal glutamic acid and glutamine residues can spontaneously cyclize to become pyroglutamate. This is one of several forms of blocked N-terminals which present a problem for N-terminal sequencing using Edman chemistry, which requires a free primary amino group not present in pyroglutamic acid. The enzyme pyroglutamate aminopeptidase can restore a free N-terminus by cleaving off the pyroglutamate residue.
Pyroglutamic acid, also known as pidolic acid, exists as two distinct enantiomers:
 

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