Cosmetic peptides raw powder GHK-CU with GMP

Tissue remodeling follows the initial phase of wound healing and stops inflammatory and scar-forming processes, then restores the normal tissue morphology. The human peptide Gly-(L-His)-(L-Lys) or GHK, has a copper 2+ (Cu(2+)) affinity similar to the copper transport site on albumin and forms GHK-Cu, a complex with Cu(2+). These two molecules activate a plethora of remodeling related processes:

                                             
(1) Chemoattraction of repair cells such as macrophages, mast cells, capillary cells;
(2) Anti-inflammatory actions (suppression of free radicals, thromboxane formation, release of oxidizing iron, transforming growth factor beta-1, tumor necrosis factor alpha and protein glycation while increasing superoxide dismutase, vessel vasodilation, blocking ultraviolet damage to skin keratinocytes and improving fibroblast recovery after X-ray treatments);
 
(4)Increases the proliferation of fibroblasts and keratinocytes; nerve outgrowth, angiogenesis, and hair follicle size.
  
                                                         
GHK-Cu stimulates wound healing in numerous models and in humans. Controlled studies on aged skin demonstrated that it tightens skin, improves elasticity and firmness, reduces fine lines, wrinkles, photodamage and hyperpigmentation. GHK-Cu also improves hair transplant success, protects hepatic tissue from tetrachloromethane poisoning, blocks stomach ulcer development, and heals intestinal ulcers and bone tissue. These results are beginning to define the complex biochemical processes that regulate tissue remodeling.
 

Current Research:

HUMAN FIBROBLASTS: Recent studies have revealed many new aspects of molecular actions of the copper-peptide GHK-Cu. Pollard at al established that GHK-Cu is able to restore function of human fibroblasts damaged by radiation treatment thus accelerate the healing and regenerative processes.

NERVE REGENERATION: In 2005, Ahmed et al. demonstrated that GHK promotes nerve regeneration. Axon regeneration was studied using collagen tubes with incorporated peptides. GHK increased the production of nerve growth factors, expression of integrins and increased the rate of regeneration of myelinated nerve fibers.

STEM CELLS: In 2009, a group of researchers from the Seoul National University (Republic of Korea) demonstrated that the copper-peptide GHK-Cu stimulated proliferation of keratinocytes and increased expression of integrins and p63 protein in the epidermal stem cells. Since p63 is considered to be an important marker of stem cell and anti-senescence protein, the authors concluded that GHK-copper is able to revive the proliferative potential of epidermal stem cells and increase their ability to repair tissue.

ANTI-CANCER EFFECTS: In 2010, Hong Y. et al. (Department of Colorectal Surgery, Singapore General Hospital, Singapore) demonstrated that GHK-Cu is able to reverse the expression of certain genes involved in metastatic spreading of colon cancer. GHK-Cu was effective at a very low concentration.    

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