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Ethynyl estradiol 57-63-6 CAS 57-63-6
Description:
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Product Name: |
Ethynyl estradiol |
Synonyms: | NEO-ESTRONE;ETHYNYLESTRADIOL;ETHINYL ESTRADIOL;LYNORAL;17ALPHA-ETHYNYL-DELTA1,3,5(10)-ESTRA-TRIENE-3,17BETA-DIOL;17ALPHA-ETHYNYLESTRADIOL;17ALPHA-ETHINYLESTRADIOL |
CAS: | 57-63-6 |
MF: | C20H24O2 |
MW: | 296.4 |
EINECS: | 200-342-2 |
Mol File: | 57-63-6.mol |
Molecular structure |
Ethynyl Estradiol is a synthetic analog of estradiol, often used in combination with a progestin. Efficacy of administration is facilitated by the ethynyl substitution at the C-17 position, which inhibits first pass hepatic metabolism. Rapidly absorbed from gastrointestinal tract.
Function:
1 Supplement estrogen therapy adverse female gonadal function, amenorrhea, menopausal syndrome; for advanced breast cancer (in postmenopausal women), advanced prostate cancer treatment; in combination with progestin drugs, can inhibit ovulation, can be used contraceptives. The main clinical drug used to inhibit ovulation; also used in pediatric cryptorchidism and androgen excess, pituitary tumors. For the diagnosis of hypothalamic - pituitary - gonadal dysfunction, which can be carried out in accordance with gonadotropin and sex hormone levels.
2 Treatment of hypogonadotropic hypogonadism due to amenorrhea and infertility, polycystic ovarian infertility. Amenorrhea associated with weight loss, you should use correct diet weight. Also for prostate cancer (often in combination with cyproterone or fluoro methyl imide), delayed puberty or early endometrial bit different. Used primarily for inhibiting ovulation to achieve the purpose of contraception.
Item |
Specification |
Results |
Appearance |
White to creamy white, odorless, crystalline powder. |
white crystalline powder |
Solubility |
Insoluble in water; soluble in alcohol, in chloroform, in ether, in vegetable oils, and in solutions of fixed alkali hydroxides. |
Conforms |
Identification |
A:IR B:UV |
Conforms |
Specific optical rotation |
-28°~ -29.5° |
-28.3° |
Melting range |
180~186℃ |
182.5~185.3℃ |
Loss on drying |
≤1.0% |
0.45% |
Residual Solvents |
Acetone≤0.5% |
0.08% |
Assay |
97.0~102.0% (on the dried basis) |
99.43% |
Particle Size |
90% ≤10μ |
Conforms |
Conclusion |
The product complies with specification in USP34 |
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