Vincristine, Oncovin,

Details:

Chinese name: vincristine

Molecular formula: C46H56N4O10

Molecular weight: 824.96

Product use: natural plant antitumor medicine for acute leukemia and malignant lymphoma, small cell lung cancer and breast cancer.

Pharmacological action:

Vincristine is an effective component in the extraction of periwinkle of oleander. The mice Ridgeway osteosarcoma, Mecca lymphatic sarcoma, x-5563 myeloma were also useful. Vincristine has a clear anticancer effect on the cultured human liver cell line (smmc-7721), which makes most cancer cells round when the concentration of vincristine is 100ng/ml and 50ng/ml. The envelope thickens and falls off into a suspended state. When the concentration is 100ng/ml and 50ng/ml, most of the tumor cells can be rounded, the cell membrane thickens, and it falls off and is suspended. Vincristine applied concentration of 100 ng/ml to cell to the next day and 50 ng/ml in 6 days, cell proliferation inhibition rate was obviously inhibition rate of 50%, attach vincristine concentration of 100 ng/ml in the role, 8 days after proliferation inhibition rate of 99.64% at the same time with the increase of concentration of VCR, inhibition rate increased to 75.21% protein content > 25 ng/ml, the killing rate of cancer cells as well as increased. Changchun new alkali has a strong inhibitory effect on human retinoblastoma cell line hox-rb44. Half of the inhibitory concentration IC50 is 0.31 ug/ml and changchun new alkali concentration reaches 0.01 ug/ml, which can significantly induce the apoptosis of K562 cells.

Therapeutic effect:

1. Acute leukemia, especially acute leukemia in children, has a significant effect on acute lymphocytic leukemia. Malignant lymphoma. 3. Germ cell tumor. 4. Small cell lung cancer, juve sarcoma, renal cell tumor, neuroblastoma. Breast cancer, chronic lymphocytic leukemia, gastrointestinal carcinoma, melanoma and multiple myeloma.

Drug action:

Vincristine is widely used in cancer chemotherapy regimens, but as a result of chemotherapy exists serious bone marrow suppression, gastrointestinal reactions and liver and kidney damage, so it need to be taken with synchronous selenium supplements, such as the agent of malt selenium selenium weikang chewed piece, use the function of selenium auxiliary control condition, repair the stomach of the body function, and improve immunity, can stimulate the bone marrow at the same time, the recovery of bone marrow hematopoietic function, also can enhance the susceptibility of cells to the chemical drug toxicity, reduce side effects, enhance the effect of chemotherapy.