21679-14-1 factory in China Fludarabine factory in China 21679-14-1 seller in China
Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin has demonstrated efficacy in obese and overweight populations by promoting weight loss and improving metabolic parameters, and it is well tolerated.
Fludarabine Basic information |
Product Name: | Fludarabine |
Synonyms: | 2-Fluoroadeninearabinoside;9-beta-d-arabinofuranosyl-2-fluoro-9h-purin-6-amin;9-beta-d-arabinofuranosyl-2-fluoro-adenin;f-ara-a;6-AMINO-9 BETA-D-ARABINOFURANOSYLFLUOROPURINE;9-bata-d-arabinofuranosyl-2-fluoroadenine;9-BETA-D-ARABINOFURANOSYL-2-FLUORO-9H-PURIN-6-AMINE;9-BETA-D-ARABINOFURANOSYL-2-FLUOROADENINE |
CAS: | 21679-14-1 |
MF: | C10H12FN5O4 |
MW: | 285.23 |
EINECS: | 244-525-5 |
Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;API |
Mol File: | 21679-14-1.mol |
Fludarabine Chemical Properties |
mp | 265-268°C |
storage temp. | 2-8°C |
solubility | DMF: 20 mg/mL, clear, faintly yellow |
Merck | 13,4152 |
CAS DataBase Reference | 21679-14-1(CAS DataBase Reference) |
Safety Information |
Risk Statements | 23/24/25-36/37/38-39/23/24/25-39 |
Safety Statements | 26-36/37-45 |
WGK Germany | 3 |
RTECS | AU6207000 |
F | 10 |
Hazardous Substances Data | <a 0px="" border:="" padding:="" style="margin: 0px auto; padding: 0px; border: 0px; color: rgb(77, 77, 77);" substances="" title="" 21679-14-1(hazardous"="">21679-14-1(Hazardous Substances Data) |
Fludarabine Usage Synthesis |
Chemical Properties | White Solid |
Usage | Used as an antineoplastic |
Usage | A STAT-1 activation inhibita DNA synthesis inhibitor. |
Biological Activity | Purine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC 50 = 1.54 μ M in RPMI cells) triggers apoptosis through increasing Bax decreasing Bid, XIAP survivin expression. Displays anticancer activity against hematological malignancies in vivo . |
Fludarabine Preparation Products Raw materials |
Raw materials | Acetic anhydride-->Fluoroboric acid-->Boron trichloride -->2,4,5,6-TETRAAMINOPYRIMIDINE-->2,6-Diaminopurine-->DIACETAMIDE |
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