7-Ethyl-10-hydroxyc...

7-Ethyl-10-hydroxycamptothecin
7-Ethyl-10-hydroxycamptothecin
7-Ethyl-10-hydroxycamptothecin

7-Ethyl-10-hydroxycamptothecin

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100 Metric Ton

Negotiable

  • Min.Order :100 Metric Ton
  • Purity: 98%min
  • Payment Terms : L/C,T/T,Other

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86639-52-3 Sell high quality 7-Ethyl-10-hydroxycamptothecin 86639-52-3 seller in China

Quick Details

  • Appearance: light-yellow solid
  • Application:Used for research and industrial manufacture.
  • PackAge:As customer request
  • ProductionCapacity:100kg/Month |Metric Ton|Day
  • Storage:Store in a cool,dry place and keep away from direct strong light
  • Transportation:Common products:Sea/Air/Courier Dangerous Chem:Sea/Air

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Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin has demonstrated efficacy in obese and overweight populations by promoting weight loss and improving metabolic parameters, and it is well tolerated.

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Quick Details

  • ProName: 7-Ethyl-10-hydroxycamptothecin 86639-...
  • CasNo: 86639-52-3
  • Molecular Formula: C22H20N2O5
  • Appearance: detailed in specifcations
  • Application: Aripiprazole Intermediate functional...
  • DeliveryTime: within 5days
  • PackAge: as needed
  • Port: China main port
  • ProductionCapacity: 500 Metric Ton/Month
  • Purity: 99%
  • Storage: Keep in dry and cool condition
  • Transportation: by air or sea
  • LimitNum: 1 Kilogram
  • MF: C13H21O3PS

Details

7-Ethyl-10-hydroxycamptothecin Basic information
Product Name: 7-Ethyl-10-hydroxycamptothecin
Synonyms: CAMPTOTHECIN, 7-ETHYL-10-HYDROXY;4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;7-ETHYL-10-HYDROXYCAMPTOTHECIN;7-ETHYL-10-HYDROXYCAMPTOTHECINE;7-ETHYL-10-HYDROXY-CPT;SN38;10-dihydroxy-;4’:6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione,4,7-diethyl-1h-pyrano(3
CAS: 86639-52-3
MF: C22H20N2O5
MW: 392.4
EINECS:  
Product Categories: Pharmaceutical Raw Materials;Miscellaneous Natural Products;Antitumors for Research and Experimental Use;Biochemistry;Natural Plant Extract;Chiral Reagents;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Natural Anti-cancer Medical Materials and It's Derivatives;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Chiral Reagents, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;Inhibitors
Mol File: 86639-52-3.mol
7-Ethyl-10-hydroxycamptothecin Structure
 
7-Ethyl-10-hydroxycamptothecin Chemical Properties
mp 217 °C
refractive index 21.5 ° (C=0.2, THF)
storage temp. −20°C
CAS DataBase Reference 86639-52-3(CAS DataBase Reference)
 
7-Ethyl-10-hydroxycamptothecin Usage And Synthesis
Chemical Properties Light-Yellow Solid
Usage A metabolite of Irinotecan, a DNA topoisomerase inhibitor
Biological Activity Active metabolite of CPT-11 that inhibits DNA topoisomerase I (IC 50 values are 0.74 and 1.9 μ M in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC 50 values are 0.077 and 1.3 μ M respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC 50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively).
 
7-Ethyl-10-hydroxycamptothecin Preparation Products And Raw materials
Preparation Products Irinotecan
 

 

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