130693-82-2 Dorzolomide hydrochloride Dorzolomide hydrochloride
Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin has demonstrated efficacy in obese and overweight populations by promoting weight loss and improving metabolic parameters, and it is well tolerated.
Items |
Specification |
Results |
Description |
White or almost white crystalline powder |
Complies |
Identification |
a) IR spectrum b) By HPLC |
Complies |
Solubility |
Soluble in water |
Complies |
Water |
Not more than 0.5% |
0.12% |
Residue on ignition |
Not more than 0.1% |
Complies |
Specific Rotation |
-7.3 - -9.3°(C=1, methanol, 25 °C |
-8.2° |
Heavy metals |
Not more than 10ppm |
Complies |
Related compound A |
Not more than 0.5% |
0.02% |
Chromatographic purity |
Any individual impurity: Not more than 0.1% Total impurities: Not more than 0.5% |
0.02% 0.10% |
Organic volatile impurities |
THF: not more than 720ppm Ethyl acetate: note more than 5000ppm DCM: not more than 600ppm Methanol: not more than 3000ppm |
N/A N/A N/A N/A |
Purity (HPLC) |
NLT 99.0% |
99.85% |
Assay (On anhydrous basis) |
99.0% ~ 101.0% (C10H16N2O4S3.HCl) |
100.31% |
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