Neratinib

Neratinib
Neratinib
Neratinib

Neratinib

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100 Metric Ton

Negotiable

  • Min.Order :100 Metric Ton
  • Purity: 98%min
  • Payment Terms : L/C,T/T,Other

Keywords

698387-09-6 Sell high quality Neratinib produced in China factory Neratinib seller in China

Quick Details

  • Appearance: white powder
  • Application:Used for research and industrial manufacture.
  • PackAge:As customer request
  • ProductionCapacity:100kg/Month |Metric Ton|Day
  • Storage:Store in a cool,dry place and keep away from direct strong light
  • Transportation:Common products:Sea/Air/Courier Dangerous Chem:Sea/Air

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Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin has demonstrated efficacy in obese and overweight populations by promoting weight loss and improving metabolic parameters, and it is well tolerated.

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Quick Details

  • ProName: Neratinib 698387-09-6 C30H29ClN6O3
  • CasNo: 698387-09-6
  • Molecular Formula: C30H29ClN6O3
  • Appearance: detailed in specifcations
  • Application: Aripiprazole Intermediate functional...
  • DeliveryTime: within 5days
  • PackAge: as needed
  • Port: China main port
  • ProductionCapacity: 500 Metric Ton/Month
  • Purity: 99%
  • Storage: Keep in dry and cool condition
  • Transportation: by air or sea
  • LimitNum: 1 Kilogram
  • MF: C13H21O3PS

Details

Neratinib Basic information
Synthesis pathways <a effect"="" style="margin: 0px auto; padding: 0px; border: 0px; color: rgb(77, 77, 77);">Side effect
Product Name: Neratinib
Synonyms: (2e)-n-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide;neratinib;(E)-N-[4-[3-Chloro-4-[(2-pyridinyl)methoxy]anilino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide;(2E)-N-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide;N-(4-(3-Chloro-4-(2-pyridinylmethoxy)anilino)-3-cyano-7-ethoxy-6-quinolyl)-4-(dimethylamino)-2-butenamide;Unii-jjh94R3pwb;Neratinib(HKI-272);(2E)-N-[4-[[3-chloro-4-(2-pyridinylMethoxy)phenyl]aMino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(diMethylaMino)-2-butenaMide
CAS: 698387-09-6
MF: C30H29ClN6O3
MW: 557.04266
EINECS:  
Product Categories: Antineoplastic;Anti-cancer & immunity;Inhibitors
Mol File: 698387-09-6.mol
Neratinib Structure
 
Neratinib Chemical Properties
density 1.33
 
Safety Information
MSDS Information
 
 
Neratinib Usage And Synthesis
New anticancer drug Neratinib developed by US Wyeth company is an irreversible epidermal growth factor receptor(EGFR) inhibitor. It is a multiple target point of small molecule tyrosine kinase inhibitors to HER 2 and HER1 after Lapatinib, and is an irreversible ErbB receptor tyrosine kinase inhibitor. Neratinib could selectively inhibit HER-1 and HER-2 of EGFR family(IC50 was 92 nmol/L and 59 nmol/L, respectively). Clinical research showed that Neratinib exerted significant therapeutic effect on non-small cell lung cancer, colon cancer, and breast cancer.
The phaseⅡclinical trial indicated that Neratinib showed good efficacy and tolerance to HER-2 positive patients with advanced breast cancer who had been received or not Trastuzumab treatment.
The phase Ⅲ breast cancer clinical trial was complete in September 2014. The data indicated that the efficacy of Neratinib was better than Roche's Herceptin in treatment of HER-2 positive early breast cancer.
The above information is edited by the Chemicalbook of Liu Yujie.
Synthesis pathways 3-chloro-4- (pyridin-2-yl-methoxy) - aniline (2) and N- (4- chloro-3-cyano-7-ethoxy-quinolin-6-yl) - acetamide (3) are used as raw material to prepare N- [4- [3- chloro-4- (pyridin-2-yl-methoxy) anilino] -3-cyano-7-ethoxy-quinolin-6-yl] acetamide (4) by nucleophilic substitution. Deprotection of 4 was under the effect of hydrochloric acid, then was precipitated the free base in methanol
 

 

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