Lovastatin

Lovastatin

Lovastatin

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100 Metric Ton

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  • Min.Order :100 Metric Ton
  • Purity: 98%min
  • Payment Terms : L/C,T/T,Other

Keywords

75330-75-5 Lovastatin seller in China Sell high quality 75330-75-5 produced in China factory

Quick Details

  • Appearance:red rice powder
  • Application:1. Functional red yeast rice for heath...
  • PackAge:As customer request
  • ProductionCapacity:100|Metric Ton|Day
  • Storage:Store in a cool,dry place and keep away from direct strong light
  • Transportation:Common products:Sea/Air/Courier Dangerous Chem:Sea/Air

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Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products.
Main Service
1.Own made fine chemical products
2.Out sourcing and quality controlling service in China
3. COM for Chemical synthesis
4.Lab custom synthesis of API and intermadiates

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1. NMR，HPLC and COA can be supplied
2. Free sample for testing

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Lovastatin Basic information
<a cholesterol="" lowering="" agent"="" style="margin: 0px auto; padding: 0px; font-size: 12px; border: 0px;">a cholesterol lowering agent
Product Name: Lovastatin
Synonyms: )ethyl]-1-naphthalenylester;[1s-[1alpha(r*),3alpha,7beta,8beta(2s*,4s*),8abeta]]-2-methylbutanoicacid1,2,;1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobuty;2-methyl-,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-butanoicaci;3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2h-pyran-2-yl;3r,7s,8s,8ar)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[2r,4r)-tetrahydro-(1;4-hydroxy-6-oxo-2h-pyran-2-yl)ethyl)-1-naphthalenylester,(1s-(1-alpha-(r*),3;4-hydroxy-6-oxo-2h-pyran-2-yl]ethyl]-1-naphthalenyl(s)-2-methyl-butyrate
CAS: 75330-75-5
MF: C24H36O5
MW: 404.54
EINECS:  
Product Categories: Antibiotics;APIs;Intermediates & Fine Chemicals;Pharmaceuticals;API's;HMG-CoA reductase;Chiral Reagents;Heterocycles;Inhibitor;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Isotopically Labeled Pharmaceutical Reference Standard;RYTHYMOL;antibiotic;Cardiovascular APIs
Mol File: 75330-75-5.mol
Lovastatin Structure
 
Lovastatin Chemical Properties
mp 175°C
refractive index 320 ° (C=0.5, CH3CN)
storage temp. 2-8°C
Water Solubility 0.0004 mg/mL at 25 ºC
Merck 5586
CAS DataBase Reference 75330-75-5(CAS DataBase Reference)
EPA Substance Registry System Butanoic acid, 2-methyl-, (1S,3R,7S,8S,8aR)-1,2,3,7, 8,8a-hexahydro-3,7-dimethyl- 8-[2-[(2R,4R)-tetrahydro- 4-hydroxy-6-oxo-2H-pyran- 2-yl]ethyl]-1-naphthalenyl ester, (2S)-(75330-75-5)
 
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 22-24/25-36/37/39-26
RIDADR 3077
WGK Germany 3
RTECS EK7907000
HazardClass 9
PackingGroup III
Hazardous Substances Data 75330-75-5(Hazardous Substances Data)
MSDS Information
 
Lovastatin Usage And Synthesis
a cholesterol lowering agent Lovastatin is a cholesterol lowering agent isolated from a strain of Aspergillus terreus.
Lovastatin is a white, nonhygroscopic crystalline powder that is insoluble in water and sparingly soluble in ethanol, methanol, and acetonitrile.
After oral ingestion, lovastatin, which is an inactive lactone, is hydrolyzed to the corresponding β-hydroxyacid form. This is a principal metabolite and an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonate, which is an early and rate limiting step in the biosynthesis of cholesterol.
Chemical Properties White Solid
Usage antiarrhythmic
Usage Lovastatin (mevinolin) is a metabolite first isolated from Monascus ruber and later found in several other fungal species. Lovastatin is a potent inhibitor of HMG-CoA. HMG-CoA reductase is the rate-controlling enzyme of the mevalonate pathway, responsible for the biosynthesis of cholesterol. Lovastatin was developed as a drug as a hypolipemic agent.
Usage anti-hyperlipoproteinemic, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor
Usage An antihypercholesterolemic agent. A fungal metabolite, which is a potent inhibitor of HMG-CoA reductase
Biological Activity Potent, competitive inhibitor of HMG-CoA reductase (K i = 0.6 nM) therefore decreases cholesterol biosynthesis, in vitro and in vivo . Decreases CDK2, 4, 6 and cyclin E levels and induces G1 arrest and apoptosis in tumor cell lines in vitro .
 
Lovastatin Preparation Products And Raw materials
Preparation Products Simvastatin
Raw materials 2-N-BUTOXYETHYL METHACRYLATE-->HY SOY
 
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