Tacrolimus

Tacrolimus

CAS No.:

104987-11-3

Synonyms:

· FK-506;

Formula:

C44H69NO12

Exact Mass:

803.48200

Molecular Weight:

804.01800

PSA:

178.36000

LogP:

4.57690

Tacrolimus Usage And Synthesis

Chemical Properties

White Crystalline Solid

Usage

An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release.

Usage

FK-506 (Tacrolimus) is a macrolide immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system

Usage

Tacrolimus (fujimycin) was discovered as a potent inhibitor of IL2 production in a targeted search for novel immunosuppressants. Tacrolimus acts by blocking T cell proliferation in vitro by inhibiting the generation of several lymphokines, notably the original target IL-2. Tacrolimus inhibits the activity of FK-506 binding protein, Ca2+-dependent phosphatase and calcineurin, and activates NF-κB through phosphorylation and degradation of IκBα.

Usage

treatment of Cushing's syndrome

Usage

For use after allogenic organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It was first approved by the FDA in 1994 for use in liver transplantation, this has been extended to include kidney, heart,

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Appearance & Physical State:

White or off-white crystalline powder

Density:

1.19 g/cm3

Melting Point:

113-115ºC

Boiling Point:

871.7ºC at 760 mmHg

Flash Point:

481ºC

Refractive Index:

1.549

Storage Condition:

-20ºC

Vapor Pressure:

1.73E-35mmHg at 25°C