4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid

4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid

Min.Order / FOB Price:Get Latest Price

100 Metric Ton	Negotiable

100 Metric Ton

Negotiable

Min.Order :100 Metric Ton
Purity: 98%min
Payment Terms : L/C,T/T,Other

Keywords

149709-62-6 Sell high quality 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid 149709-62-6 seller in China

Quick Details

Appearance:white powder
Application:Used for research and industrial manufacture.
PackAge:As customer request
ProductionCapacity:100kg/Month |Metric Ton|Day
Storage:Store in a cool,dry place and keep away from direct strong light
Transportation:Common products:Sea/Air/Courier Dangerous Chem:Sea/Air

Superiority:

Details:

Basic information

HP90699 AHU-377 (Sacubitril) 149709-62-6

AHU-377 (Sacubitril) 149709-62-6

MF C24H29NO5 C4H11NO3

MSDS:Aviable

MW 532.6

Place of Origin:China

Synonym: Sacubitril

AHU-377 (Sacubitril) Description

AHU-377 (Sacubitril) is a prodrug which is activated in vivo by hydrolytic enzyme esterases to form an active compound LBQ657 that selectively and potently inhibits the enzyme Neprilysin with Ki at low nM. Neprilysin is a protease responsible for the degradation of atrial and brain natriuretic peptides. Inhibition of the enzyme prevents the degradation of natriuretic peptides and activates cGMP signaling pathways that regulate volume and blood pressure. AHU-377 (Sacubitril) is an investigational antihypertensive drug being studied for use in combination with Valsartan (molar ratio: 1:1) (Our Prod No. CT-VALS). The combination drug, known as LCZ696, is in clinical trials for the treatment of heart failure.

AHU-377 (Sacubitril) Structual

Purity

99% min

AHU-377 (Sacubitril) Storage condition

Store at 0°C (short term), -20°C (long term) desiccated

AHU-377 Documents provide

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4-(((2S,4R)-1-([1,1...