A77 1726

A77 1726

A77 1726

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100 Gram

Negotiable

  • Min.Order :100 Gram
  • Purity: 98% min
  • Payment Terms : L/C,T/T,Other

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163451-81-8 factory in China A77 1726 factory in China 163451-81-8 seller in China

Quick Details

  • Appearance:White Solid
  • Application:Used for research and industrial manufacture.
  • PackAge:As customer request
  • ProductionCapacity:100|Kilogram|Month
  • Storage:Store in a cool,dry place and keep away from direct strong light
  • Transportation:Common products:Sea/Air/Courier Dangerous Chem:Sea/Air

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A77 1726 Basic information
Product Name: A77 1726
Synonyms: A77 1726 (Teriflunomide);LeflunoMide EP IMpurity B;A 1726;Flucyamide;HMR 1726;(Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide
CAS: 163451-81-8
MF: C12H9F3N2O2
MW: 270.2072696
EINECS:  
Product Categories: Metabolites & Impurities;Tyrosine Kinase Inhibitors
Mol File: 163451-81-8.mol
A77 1726 Structure
 
A77 1726 Chemical Properties
Melting point  229-232°C
storage temp.  Hygroscopic, -20°C Freezer, Under Inert Atmosphere
 
Safety Information
Hazard Codes  Xn
Risk Statements  22
MSDS Information
 
 
A77 1726 Usage And Synthesis
Chemical Properties White Solid
Uses The active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function.
Definition ChEBI: An enamide obtained by formal condensation of the carboxy group of (2Z)-2-cyano-3-hydroxybut-2-enoic acid with the anilino group of 4-(trifluoromethyl)aniline. Used for the treatment of relapsing forms of multiple sclerosis and rheumatoid arthritis.
Uses A-771726 is the active metabolite of leflunomide, a prodrug approved by the FDA for treatment of rheumatoid arthritis. A-771726 reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines. It prevents activated lymphocytes from accumulating sufficient pyrimidines to support DNA synthesis (IC50s = 0.09, 3.5, and 12.5 μM for rat, mouse, and human, respectively). At higher doses, A-771726 inhibits tyrosine kinases responsible for early T cell and B cell signaling in the G0/G1 phase of the cell cycle. A-771726 has also been shown to inhibit the production of prostaglandin E2 in synoviocytes activated by TNF-α and IL-1α (IC50s = 7 and 3 μM, respectively) as well as inhibit MMP-1 and IL-6 production at concentrations >10 μM.[Cayman Chemical]

 

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