Pramoxine hydrochlo...

Pramoxine hydrochloride 99%
Pramoxine hydrochloride 99%
Pramoxine hydrochloride 99%
Pramoxine hydrochloride 99%
Pramoxine hydrochloride 99%

Pramoxine hydrochloride 99%

Min.Order / FOB Price:Get Latest Price

1 Kilogram

FOB Price: USD 1.0000

  • Min.Order :1 Kilogram
  • Purity: 99%
  • Payment Terms : L/C,T/T,

Keywords

Pramoxine hydrochloride/cas:637-58-1 cas:637-58-1 Pramoxine hydrochloride

Quick Details

  • Appearance:powder
  • Application:intermediate
  • PackAge:fiber can/aluminum foil bag
  • ProductionCapacity:50|Kilogram|Day
  • Storage:20℃
  • Transportation:by air or by sea

Superiority:

Four novel pramoxine HCl (PAM) selective electrodes were investigated with 2-nitrophenyl octylether as a plasticiser in a polymeric matrix of polyvinyl chloride (PVC). Sensor 1 was fabricated using sodium-tetraphenylborate (TPB) as an anionic exchanger without incorporation of an ionophore. Sensor 2 used 2-hydroxy propyl -cyclodextrin as an ionophore, while sensors 3 and 4 were constructed using 4-sulfocalix-6-arene and 4-sulfocalix-8-arene respectively as ionophores. Linear responses of PAM within the concentration ranges of 1.0 × 10-4 to 1.0 × 10-2 mol L-1 and 1.0 × 10-5 to 1.0 × 10-2 mol L-1 were obtained using sensors 1 and 2, respectively and 1.0 × 10-6 to 1.0 × 10-2 mol L-1 were obtained using sensors 3 and 4. Nernstian slopes of 50.4 ± 0.6, 54.3 ± 0.8, 56.3 ± 0.3 and 59.1 ± 0.5 mV/decade over the pH range of 3.0-6.0 were observed. The selectivity coefficients of the developed sensors indicated excellent selectivity for PAM. The utility of 2-hydroxy- propylcyclodextrin (2HP-β-CD) and 4-sulfocalix [6,8] arene (SC 6, 8) as ionophores had a significant influence on increasing the membrane sensitivity and selectivity of sensors 2, 3 and 4 compared to sensor 1. The proposed sensors displayed useful analytical characteristics for the determination of PAM in bulk powder, pharmaceutical formulation, and in biological fluid. Validation of the method showed the suitability of the proposed electrodes for the use in the quality control assessment of the drug. Furthermore, statistical comparison between the results obtained by the proposed method and the official method of the drug was performed and no significant difference was found.

Details:

Pramocaine
Systematic (IUPAC) name
4-[3-(4-butoxyphenoxy)propyl]morpholine
Clinical data
AHFS/Drugs.com International Drug Names
MedlinePlus a682429
Pregnancy cat.  
Legal status OTC (CA) POM (UK) -only(US) (withhydrocortisone)
Routes Topical, rectal
Identifiers
CAS number 140-65-8  637-58-1
ATC code D04AB07 C05AD07
PubChem CID 4886
ChemSpider 4717 Yes
UNII 068X84E056 Yes
ChEBI CHEBI:8357 Yes
ChEMBL CHEMBL1198 Yes
Chemical data
Formula C17H27NO3 
Mol. mass 293.401 g/mol

 

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