CasNo.149506-35-4,Dapagliflozin factory,(149506-35-4) Suppliers

10 Gram	FOB Price: USD 3.0000

Min.Order :10 Gram
Purity: 99.00%
Payment Terms : T/T,,MoneyGram,Other

Keywords

Dapagliflozin powder Dapagliflozin price Dapagliflozin

Quick Details

Appearance:white powder
Application:in research
PackAge:Aluminum foil bag/ as requirements
ProductionCapacity:800|Kilogram|Month
Storage:Store in a cool dry place and keep away from strong light
Transportation:by air or by sea

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Details:

Product Name: Dapagliflozin

Cas No: 149506-35-4

Molecular Formula: C21H25ClO6

Appearance: white powder

Application: Research purpose

Delivery Time: within 1-3 working day

Package: 1kg/Aluminum foil bag

Production Capacity: 500 Kilogram/Month

Purity: 98.5%Storage: Kept in a cool, dry and ventilated place

.Transportation: by air

Min order: 1 Gram

Dapagliflozin , the trade name is Farxiga in the U.S. and Forxiga in the EU and Russia. It is a drug of the gliflozin class, used to treat type 2 diabetes. It was developed by Bristol-Myers Squibb in partnership with AstraZeneca.

Mechanism of action

Dapagliflozin inhibits subtype 2 of the sodium-glucose transport proteins (SGLT2) which are responsible for at least 90% of the glucose reabsorption in the kidney. Blocking this transporter mechanism causes blood glucose to be eliminated through the urine.In clinical trials, dapagliflozin lowered HbA1c by 0.6 versus placebo percentage points when added to metformin.

Selectivity

The IC50 for SGLT2 is less than one thousandth of the IC50 for SGLT1 (1.1 versus 1390 nmol/L), so that the drug does not interfere with intestinal glucose absorption.

Research

Clinical trials to assess effectiveness for patients with type 1 diabetes are underway.