Medical Raw Material Pramipexole CAS 104632-26-0 to Treat Parkinson′s Disease
Pramipexole Descriptions:
Pramipexole is a dopamine agonist belonging to the same class of drugs as Cabergoline. The primary purpose of this drug is in the treatment of Parkinson's disease. Pramipexole is most commonly found under the brand names Sifrol, Mirapexin and Mirapex, although generics are also available. Mirapex is the most well known brand by Boehringer Ingelheim Pharmaceuticals. Along with treating Parkinson's, Pramipexole is also prescribed for the treatment of restless legs syndrome. The drug has also shown promising signs in the treatment of bipolar depression, although it has never officially held this label.
Pramipexole is used alone or with other medications to treat the symptoms of Parkinson's disease (PD; a disorder of the nervous system that causes difficulties with movement, muscle control, and balance), including shaking of parts of the body, stiffness, slowed movements, and problems with balance. Pramipexole is also used to treat restless legs syndrome (RLS; a condition that causes discomfort in the legs and a strong urge to move the legs, especially at night and when sitting or lying down). Pramipexole is in a class of medications called dopamine agonists. It works by acting in place of dopamine, a natural substance in the brain that is needed to control movement.
Pramipexole Applications:
Pramipexole is a dopamine-receptor agonist. It is a medicine that acts on the same receptors (tiny areas in the brain) as dopamine. In effect, it acts like a substitute for dopamine. It may be used alone or in combination with other medicines used to treat Parkinson's disease.
Pramipexole can also be used to treat restless legs syndrome. This is an uncomfortable feeling in your legs, which gives you the urge to move your legs to get relief. Pramipexole can help when these symptoms are severe enough to cause distress.
Pramipexole is available as immediate-release tablets and as prolonged-release tablets. The immediate-release tablets can be taken by people with Parkinson's disease or people with restless leg syndrome. The prolonged-release tablets are suitable for people who have Parkinson's disease.
Pramipexole Administration:
Pramipexole is found in tablet form and is taken orally. The drug's half-life is approximately 8-12 hours in duration. It is most commonly found in 0.125mg, 0.25mg, 0.5mg, 0.75mg, 1mg and 1.5mg strengths. For the treatment of Parkinson's you will find dosing is somewhat heavy compared to other issues of treatment. Doses for Parkinson's treatment normally start low in order to allow the body to accustom starting at 0.125mg 2-3 times per day and increases gradually over several weeks reaching anywhere from 0.75-1.5mg 2-3 times per day depending on need.
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