High purity 99% Afatinib,afatinib dimaleate (EGFR1/HER2 inhibitor) in stock CAS NO.850140-72-6 manufacturer

Superiority:

Product Description

Afatinib

Afatinib Brief Description

CAS No.:850140-72-6

MF:C24H25ClFN5O3

MW:485.9384032

Competitive price with high quality

Conforms to BP/USP/EP/FCC

Afatinib COA

Medical Use

AfatIt has received regulatory approval for use as a treatment for non-small cell lung cancer,although there is emerging evidence to support its use in other cancers such as breast cancer.

In October 2010 a Phase III trial in NSCLC patients called Lux-Lung 5 began with this drug.Fall 2010 interim results suggested the drug extended progression-free survival threefold compared to placebo, but did not extend overall survival.In May 2012, the Phase IIb/III trial Lux-Lung 1 came to the same conclusion.

In January 2015 a Phase III trial in people with NSCLC suggested the drug extended life expactancy in stage IV NSCLC Adenocarcinoma with EGFR Mutation type del 19-positive tumors, compared to cisplatin-based chemotherapy by a year (33 months vs. 21 months).

Phase II results for breast cancer that over-expresses the protein human epidermal growth factor receptor 2 (Her2-positive breast cancer) were described as promising by the authors, with 19 of 41 patients achieving benefit from afatinib.[9] Double-blind Phase III trials are under way to confirm or refute this finding. Her2-negative breast cancers showed limited or no response to the drug.

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Our advantages:

1, High quality with competitive price:

1) Standard:BP/USP/EP/Enterprise standard

2) All Purity≥99%

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1) Parcel can be sent out in 24 hours after payment.Tracking number available

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