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1 Gram |
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Miconazole nitrate powder Miconazole nitrate 75319-48-1
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1) Product Name: Miconazole powder //CAS 22832-87-7//Miconazole nitrate
2) CAS NO: 22832-87-7
3) Active ingredients:Miconazole nitrate
4) Specification: 99%
5) Testing Method:HPLC
6) Appearance:White or almost white crystal powder
Specification |
Standard |
|
Appearance |
White or almost white crystal powder |
|
Identification |
|
Similar to standard |
Appearance of solution |
The solution is clear and not more intensely cloured than reference solutions Y7 |
|
Solubility |
Very slightly soluble in water; soluble in methanol; slightly soluble in alcohol |
|
Angle of optical rotation |
-0.10 ----+0.10 |
|
Related substances |
Each impurity |
≤0.25% |
Total imurity |
≤0.5% |
|
Melting point |
178-182°C |
|
Loss on drying |
≤0.5% |
|
Residue on ignition |
≤0.1% |
|
Assay ( on dry basis) |
98.5-102% |
Function:
Miconazole nitrate is also called Daknin, he's forest, miconazole, miconazole, miconazole, miconazole, synthetic 1- benzene ethyl imidazole derivatives are imidazole broad-spectrum antifungal agents is a common drug for the treatment of skin tinea, no hormones, no side effects, the the main active ingredient for miconazole. Miconazole nitrate is rarely used in China now. Its antibacterial spectrum, antibacterial activity and mechanism of action are similar to clotrimazole. It can be used as an alternative to amphotericin B in the treatment of deep fungal infections. It is suitable for the treatment of systemic and disseminated infections caused by Cryptococcus neoformans and Candida albicans. Oral absorption effect is poor, after local medication mainly stay in the lesion site, absorbed into the body very little. In vivo distribution in the body and the liquid, can penetrate into the joint, and peritoneal inflammation in the vitreous body, but in the sputum, saliva in low concentration of blood cerebrospinal fluid barrier penetration is poor, not easily through the blood-brain barrier. The binding rate of plasma protein was 90%. Metabolic inactivation through liver is an inactive metabolite.
Miconazole nitrate is an antifungal drug, the drug is Daktarin we are familiar with the commonly used in the treatment of skin tinea, by inhibiting the biosynthesis of the fungal cell membrane components of ergosterol, destroy the structure of cell membrane, the cell membrane permeability increased, resulting in the leakage of intracellular components and inhibit glucose, prevent nutrient intake, eventually fungal cell death, suitable for the treatment of tinea corporis, tinea cruris, tinea manus, tinea pedis, tinea versicolor and fungal paronychia and by yeast (such as Candida) caused by Gram positive bacteria and vaginal infection and secondary infection, external ear infections, bacterial skin infections are effective.
Shaanxi Mingqi Chemical Co., Ltd is committed to the development of import and export trade in the production, operation and plant extracts of pharmaceutical raw materials and intermediates. It has trade with other Asian countries and Europe, the Americas and African countries. Important exporters of pharmaceutical chemical raw materials and the world's latest importers of pharmaceutical raw materials.
Shaanxi Mingqi Chemical Co., Ltd has always been adhering to the company to market-oriented, customer-centric, with professional and enterprising team spirit and the company's strong financial strength, to provide customers with fast, high quality and efficient services, and always " To benefit customers "for the purpose.
In the pharmaceutical raw materials and intermediates export business, the company by virtue of years of accumulated experience and high quality and reasonable talent structure, accurate grasp of the market, not only with a number of well-known domestic production enterprises to establish a long-term stable strategic cooperative relations in the global pharmaceutical chemical raw materials And chemical intermediates on the market also won the loyal customer base and a very strong strategic partner, set up a professional image of the outsourcing of pharmaceutical procurement. On the basis of continuing to develop the existing export trade business, the Company has formulated the idea of establishing independent research and development center and constructing the production base of pharmaceutical and chemical products according to the future development trend of the pharmaceutical and chemical industry, and strives to establish the combination of R & D, manufacturing and trade Of the business development model.
While actively expanding their business and creating economic profits, enterprises do not forget their social responsibility, and actively participate in greening trees, poor students and other social activities, and become a tradition for many years, creating a good social benefits.
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