CasNo.154229-19-3,CAS:154229-19-3 Abiraterone 99%,(154229-19-3) Suppliers

1 Kilogram	Negotiable

Min.Order :1 Kilogram
Purity: 99.5%
Payment Terms : T/T,,MoneyGram,Other

Keywords

Abiraterone Abiraterone high purity Androsta-5,16-dien-3-ol,17-(3-pyridinyl)-, (3b)-

Quick Details

Appearance:White powder
Application:Medicine
PackAge:according to customers' requirements
ProductionCapacity:100|Kilogram|Week
Storage:store in cool and dry
Transportation:by sea or by air

Superiority:

Introduction

Abiraterone acetate, the active ingredient of ZYTIGA is the acetyl ester of abiraterone. Abiraterone is an inhibitor of CYP17 (17α-hydroxylase/C17,20-lyase). Each ZYTIGA tablet contains 250 mg of abiraterone acetate. Abiraterone acetate is designated chemically as (3β)-17-(3-pyridinyl)androsta-5,16-dien-3-yl acetate

Abiraterone acetate is a white to off-white, non-hygroscopic, crystalline powder. Its molecular formula is C26H33NO2and it has a molecular weight of 391.55. Abiraterone acetate is a lipophilic compound with an octanol-water partition coefficient of 5.12 (Log P) and is practically insoluble in water. The pKa of the aromatic nitrogen is 5.19.

Inactive ingredients in the tablets are colloidal silicon dioxide, croscarmellose sodium, lactose monohydrate, magnesium stearate, microcrystalline cellulose, povidone, and sodium lauryl sulfate.

English name: Abiraterone acetate

Synonyms:Abirateroneacetate;CB 7630;(3β)-17-(pyridin-3-yl)androsta-5,16-dien-3-yl acetate

Specification: 98%

CAS NO.:154229-18-2

Appearance: White crystalline powder

Molecular weight: 391.55

Molecular formula:C26H33NO2

Function

Abiraterone is a drug used in castration-resistant prostate cancer. It is formulated as the prodrug abiraterone acetate. Abiraterone can be used as a prostate cancer drug treatment. Abiraterone is a inhibitor of CYP17. It can be used to treat CRPC.

Application
Abiraterone is used as pharmaceutical raw material.

Specification

Item	Specification	Result
Appearance	White crystalline powder	Complies
Related substance (HPLC)	Total impurity ≤0.5% Max single impurity ≤0.1%	0.2% 0.06%
Odor	Characteristic	Complies
Assay	99%	99.8%
Sieve analysis	100% pass 80 mesh	Complies
Loss on Drying Residue on Ignition	≤1.0% ≤1.0%	0.12% 0.09%
Heavy Metal	<10ppm	Complies
As	<0.1ppm	0.05ppm
Pb	<0.1ppm	0.05ppm
Cd	<0.1ppm	0.05ppm
Residual Solvents	<100ppm	Complies
Residual Pesticide	Negative	Complies
Microbiology
Total Plate Count	<1000cfu/g	Complies
Yeast & Mold	<100cfu/g	Complies
E.Coli

Details:

Kono Chem Co.,Ltd is a leading producer of standardized herbal extracts, natural active ingredients and APIs for pharmaceutical, health food and cosmetic industries.

The botanical raw materials are subject to strict selection and inspection, and extracts are manufactured according to methods developed by Pioneer. They include inspections to guarantee a high quality standard from both analytico-chemical and therapeutic points of view, and take into consideration the state of art in different fields: research and development, analyses, processes and machinery, therapeutic applications on a scientific basis.

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