CasNo.4759-48-2,CAS:4759-48-2 Isotretinoin low price,(4759-48-2) Suppliers

1 Kilogram	Negotiable

Min.Order :1 Kilogram
Purity: 99.5%
Payment Terms : T/T,Other

Keywords

Isotretinoin Isotretinoin high purity 13-cis-Retinoic acid

Quick Details

Appearance:White powder
Application:Pharmaceutical
PackAge:according to customers' requirements
ProductionCapacity:100|Kilogram|Week
Storage:store in cool and dry
Transportation:by sea or by air

Superiority:

Description:

It is used on the skin (topically) in the treatment of mild to moderate acne.

Product name: Vitamin A acid Tretinoin INCI Name: Vitamin A acid
CAS. NO.: 4759-48-2

Chemical name:
3, 7-dimethly-9-(2, 6-trimethly-1-cylohexane)-2, 4, 6, 8-pelartetaenoic acid

Character: Yellow acicular crystals, trans tretionoirum mainly. Easily dissolved in chloroform, dichoromethane and dissolved in carbinol, ethanol and also dissolved in vegetable oil and lipid. Instability exposed in light and caloricr, easily absorbing moisture and metamorphosed in water.
Quality index: Conform CP2005/BP2002/USP26
Melting point: About 182 centigrade
Loss on drying: ≤0.5%
Heavy metals: ≤0.002% Content: ≥98~102%

Function:

Both tretionirum and Vitamin A can stimulate skin growth and keep epidermic normal. Howerver, to spread on part of skin has no actual effect. Taking orally vitamin A is benefit to treat skin disorders. Applying vitamin A acid to skin partly could produce intensive pharmacological action. External use can slow down skin aging process for solarization, remove tiny wrinkles, and reduce skin roughness, so skin will become ruddy.

Side-effect and Notice:
Don`t spread it in thin skin. Proper lower concentration (no more than 0.025%)can avoid such reaction as scalp off, Scorching fever and erythema, which is caused by drastic dilation of blood vessel. Please insist on using the product and you will get preferable curative effect when you find such normal reaction as erythema, scorch fever and hypodynia. Discontinue it and apply some oleiferous skin-care products to the skin site, if the reaction is severe. Cold cream concentration less than 0.025, show some effect upon treating acne and skin roughness kept cool and closed.

Specification:

Test/Observation	Specifications	Result
Assay Content HPLC	97%-102%	99.12%
Appearance	Fine Powder	Complies
Identification	IR. UV	Complies
Odor	Characteristic	Complies
Mesh	100% pass 100 mesh	Complies
Residue on ignition	MAX 0.1%	Complies
Loss on drying %	MAX 0.5%	0.39%
Ash %	MAX. 1.0%	0.52%
Heavy metals PPM	MAX. 0.002%	Complies
Limit of Isotretinoin	MAX5.0%	3.9%
Organic Volatile Impurities	Meet The Requirements	Complies
Microbiology Total Plate Count Yeast & Mold E. Coli Salmonella	< 1000cfu/g < 100cfu/g Negative Negative	82cfu/g Negative Complies Complies
Conclusion	Conform with specification

Application:

1. Retinoic Acid/Tretinoin is widely applied in pharmaceutical field, mainly used for

the cure of dermatonosus like acne, ichthyosis and psoriasis abnormal, etc..

Retinoic Acid/Tretinoin can be made into tretinoin or retinoic acid cream to cure

acne or other unhealthy skin.

2. Retinoic Acid/Tretinoin is used for skin keratinocytes-resistant drugs and cell-

induced differentation drug.

Details:

Kono Chem Co.,Ltd is a leading producer of standardized herbal extracts, natural active ingredients and APIs for pharmaceutical, health food and cosmetic industries.

The botanical raw materials are subject to strict selection and inspection, and extracts are manufactured according to methods developed by Pioneer. They include inspections to guarantee a high quality standard from both analytico-chemical and therapeutic points of view, and take into consideration the state of art in different fields: research and development, analyses, processes and machinery, therapeutic applications on a scientific basis.

With our phytopharmaceutical background and knowledge through experience, PIONEER can also provide a wide range of analytical services and reference substances to our clients. In addition, We also manufacture pharmaceutical raw materials of nucleotide species, mainly including as below: SAM-e Tosylate Disulfate; SAM-e 1,4-Butanedisulfonate; Polycytidylic Acid; Polyinosinic Acid; Adenosine Triphosphate Disodium; and Cytidine Triphosphate Disodium; these items are our strongest advantage in China. Meanwhile, we can do custom made pharmaceutical ingredients depending on our professional experts in the pharmaceutical and chemistry industry.

Recently, Kono Chem has been working hard on the research and development of new cardiovascular and anesthesia drugs, we have got good achievements; moreover, we also offer natural anticancer drugs and other pharmaceutical intermediates. As a GMP standardized manufacturer, our products can meet or even exceed the standards of CP2010, USP32, BP2005 and EP4. Presently, 80% and above of our products have been well-recognized in dozens of countries and regions, such as USA, EU, South America and Southeast Asia. There are experienced technicians working for our institutes now, all of them are skilled. Pioneer is looking forward to cooperating with friends all over the world for getting collaborative development; we are willing to work with you to develop new drugs and expand new business, let's work together for bright future.