High quality Tadalafil 99% CAS 171596-29-5 with lower price
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| 1 Kilogram |
FOB Price:USD 400.0000 -450.0000 |
- Min.Order :1 Kilogram
- Purity: 99.90%
- Payment Terms : L/C,T/T,,MoneyGram,Other
Keywords
Tadalafil 171596-29-5 Tadalafil 99%
Quick Details
- Appearance:Solid powder
- Application:Cialis (or Tadalafil) was developed by American pharmaceutical company Lilly. It is used to treat erectile dysfunction and belongs to a second generation of PDE5 inhibitors. CAS 171596-29-5
- PackAge:drum and bag
- ProductionCapacity:3000|Kilogram|Month
- Storage:in sealed air resistant place
- Transportation:by sea or air
Superiority:
| Product Name: | Tadalafil |
| Synonyms: | TADALAFIL;CIALIS;IC 351;(6r,12ar)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione;TADALAFIL(CIALIS);Taladafil (cialis);Cialis/taladafil;Cialis(IC351) |
| CAS: | 171596-29-5 |
| MF: | C22H19N3O4 |
| MW: | 389.4 |
| EINECS: | 200-835-2 |
| Product Categories: | Active Pharmaceutical Ingredients;Cnbio;Erectile Dysfunction;Pyridines ,Halogenated Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Steroid and Hormone;Inhibitor;API;Tadalafil;NUCYNTA |
| Mol File: | 171596-29-5.mol |
Details:
| Tadalafil Basic information |
| Product Name: | Tadalafil |
| Synonyms: | TADALAFIL;CIALIS;IC 351;(6r,12ar)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione;TADALAFIL(CIALIS);Taladafil (cialis);Cialis/taladafil;Cialis(IC351) |
| CAS: | 171596-29-5 |
| MF: | C22H19N3O4 |
| MW: | 389.4 |
| EINECS: | 200-835-2 |
| Product Categories: | Active Pharmaceutical Ingredients;Cnbio;Erectile Dysfunction;Pyridines ,Halogenated Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Steroid and Hormone;Inhibitor;API;Tadalafil;NUCYNTA |
| Mol File: | 171596-29-5.mol |
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| Tadalafil Chemical Properties |
| Melting point | 298-300°C |
| Fp | 2℃ |
| storage temp. | Hygroscopic, -20 C Freezer, Under Inert Atmosphere |
| solubility | DMSO: soluble20mg/mL, clear |
| color | white to beige |
| CAS DataBase Reference | 171596-29-5(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | F,Xn |
| Risk Statements | 11-20/21/22-36 |
| Safety Statements | 16-36/37 |
| RIDADR | UN 1648 3 / PGII |
| RTECS | UQ4431050 |
| Hazardous Substances Data |
| Tadalafil Usage And Synthesis |
| Indications and uses | Cialis (or Tadalafil) was developed by American pharmaceutical company Lilly. It is used to treat erectile dysfunction and belongs to a second generation of PDE5 inhibitors. Studies show that Cialis works very quickly, taking effect in around 15-20 minutes, and has a prolonged effect that can last for up to 36 hours. T1/2 is 17.5h. |
| Clinical Research | In a study of 348 cases of mild to severe erectile dysfunction, patients were randomly given 20mg of Cialis or a placebo. Results showed that in comparison to the placebo group, patients who took Cialis experienced improved intercourse success in the 24-36 hours following medication, with many patients achieving successful sexual intercourse twice in 36 hours. Side effect rate and severity were also no different from those of the placebo group. Over 5% of patients in the Cialis group experienced headaches and indigestion. |
| Side effects | No severe negative reactions. No perceived facial flushing or sight abnormalities following medication. Rare cases of headache and indigestion. |
| Warnings and precautions | Patients currently taking nitrates, experiencing angina pectoris, suffering from heart disease, patients who have unregulated hypertension or hypotension, or patients who have had a stroke in the past 6 months should not take Cialis. |
| Description | Tadalafil (market name “Cialis” or “Adcirca”) is a kind of PDE5 inhibitor used for the treatment of erectile dysfunction, benign prostatic hypertrophy and pulmonary arterial hypertension. The effect of Tadalafil is relaxing the blood vessels muscles and increasing the blood flow into the corpus cavernosum. The mechanism of action of tadalafil is through inhibiting the activity of the cGMP specific phosphodiesterase type 5 (PDE5). PDE5 degrades cGMP in the corpus cavernosum located around the penis. Therefore, tadalafi leads to the increased concentration of cGMP which further causes the smooth muscle relaxation and increased blood flow into the corpus cavernosum. Some clinical studies also implied that tadalafil could improve endothelia function in men with increased cardiovascular risk and lower the urinary tract symptoms secondary to benign prostatic hyperplasia. |
| Chemical Properties | White to Off-White Cyrstalline Solid |
| Uses | Used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor |
| Uses | analgesic, norepinephrine uptake blocker, mu-opiod receptor agonist |
| Definition | ChEBI: A pyrazinopyridoindole that is 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione substituted at position 2 by a methyl group and at position 6 by a 1,3-benzodioxol-5-yl group (the 6R,12aR |
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