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Loperamide hydrochloride Loperamide hydrochloride high purity [2-[4-[(R)-(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-acetic acid dihydrochloride
Description:
Other name: [2-[4-[(R)-(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-acetic acid dihydrochloride
CAS NO.: 130018-87-0
MF: C21H27Cl3N2O3
MW: 461.80968
InChI: 1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H/t21-;;/m1../s1
Melting point: 215-220ºC
Appearance: White crystall, white crystall, soluble in alcohols and water.
Standard: USP/BP/CP/EP
Odor: odorless
Function:
Levocetirizine hydrochloride is a medication prescribed to treat symptoms of seasonal allergies and hives. These symptoms can include sneezing, a runny nose, and watering eyes, as well as itching and rashes. This antihistamine can help alleviate allergy symptoms by inhibiting the actions of the chemical histamine in the body.
Specification:
BP2007 STANDARD:
SPECIFICATIONS |
STANDARD BP2007 |
RESULTS |
APPEARANCE |
WHITE OR OFF-WHITE CRYSTALLINE POWDER |
CONFORMS |
IDENTIFICATION |
UV: similar to reference standard(285+/-2nm) IR: similar to the reference standard |
CONFORMS |
RESIDE ON IGNITION |
≤0.1% |
0.03% |
HAEVY METALS |
≤20ppm |
CONFORMS |
LOSS ON DRYING |
≤0.3% |
0.11% |
MELTING POINT |
164-168°C |
166-167°C |
5-Methylisoxazole-carboxylic acid |
≤0.1% |
0.06 |
Leflunomide related compound A |
≤0.01% |
NONE |
Leflunomide related compound B |
≤0.3% |
NONE |
N-(2’-Trifluoromethyphenyl)-5-methylisoxzole-4-carboxomide |
≤0.1% |
NONE |
2-Cyano-acetic acid-(4’-trifluoromethyl)-anilide |
≤0.1% |
NONE |
Leflunomide related compound C |
≤0.1% |
0.004 |
Total impuritie (excluding leflunomide related compound B and leflunomide related compound C ) |
≤0.2% |
0.1% |
Any other individual impurity |
≤0.1% |
≤0.1% |
Total impurities |
≤0.4% |
0.15% |
Assay |
98.0-102.0% |
99.84% |
PACKAGING AND STORAGE:Preserve in a well-closed container, store at a temperature not exceeding 30°C. |
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CONCLUSION: THE PRODUCT CONFORMS TO BP2007 STANDARD. |
Kono Chem Co.,Ltd is a leading producer of standardized herbal extracts, natural active ingredients and APIs for pharmaceutical, health food and cosmetic industries.
The botanical raw materials are subject to strict selection and inspection, and extracts are manufactured according to methods developed by Pioneer. They include inspections to guarantee a high quality standard from both analytico-chemical and therapeutic points of view, and take into consideration the state of art in different fields: research and development, analyses, processes and machinery, therapeutic applications on a scientific basis.
With our phytopharmaceutical background and knowledge through experience, PIONEER can also provide a wide range of analytical services and reference substances to our clients. In addition, We also manufacture pharmaceutical raw materials of nucleotide species, mainly including as below: SAM-e Tosylate Disulfate; SAM-e 1,4-Butanedisulfonate; Polycytidylic Acid; Polyinosinic Acid; Adenosine Triphosphate Disodium; and Cytidine Triphosphate Disodium; these items are our strongest advantage in China. Meanwhile, we can do custom made pharmaceutical ingredients depending on our professional experts in the pharmaceutical and chemistry industry.
Recently, Kono Chem has been working hard on the research and development of new cardiovascular and anesthesia drugs, we have got good achievements; moreover, we also offer natural anticancer drugs and other pharmaceutical intermediates. As a GMP standardized manufacturer, our products can meet or even exceed the standards of CP2010, USP32, BP2005 and EP4. Presently, 80% and above of our products have been well-recognized in dozens of countries and regions, such as USA, EU, South America and Southeast Asia. There are experienced technicians working for our institutes now, all of them are skilled. Pioneer is looking forward to cooperating with friends all over the world for getting collaborative development; we are willing to work with you to develop new drugs and expand new business, let's work together for bright future.
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