AMG-3969

Min.Order / FOB Price:Get Latest Price

5 Gram	Negotiable

5 Gram

Negotiable

Min.Order :5 Gram
Purity: ≥98%

Keywords

AMG-3969 AMG3969 AMG 3969

Quick Details

Appearance:
Application:For laboratory use only- not intended for drug manufacturing, not for household, human or animal consumption
PackAge:
ProductionCapacity:1|Kilogram|Quarter
Storage:room temperature
Transportation:by air

Superiority:

We are a CRO company, and our Research and Development team is consisted of PhDs and Masters in chemistry and pharmacy.

We are committed to protect our customer’s privacy with the highest level of ethical standard. Our dedicated team will follow up on every order and provide instant feedback on the status to our customer.

We stand behind our product by providing a complete QA report. The test data of customer order can be provided upon request.

We make our efforts to offer customer innovative, customized, high-quality service.

Our custom manufacturing encompasses everything from pharmaceutical intermediates to API.

Details:

AMG-3969 is a potent glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor with an IC₅₀ of 4 nM. IC50 & Target: IC50: 4 nM (GK-GKRP).In Vitro: AMG-3969 exhibits potent cellular activity with an EC₅₀ of 0.202 μM and IC₅₀ of 4 nM. It potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation in vitro (isolated hepatocytes). In Vivo: AMG-3969 has good in vivo pharmacokinetic (PK) properties in rats (75%) and significantly lowers blood glucose levels in a dose-dependent manner db/db mice. AMG-3969 (100 mg/kg) demonstrates significant reductions in blood glucose with robust efficacy (56% reduction) observed at the 8 h time point. AMG-3969 demonstrates dose-dependent efficacy in three models of diabetes: diet induced obese (DIO), ob/ob and db/db mice; however,AMG-3969 is ineffective in lowering blood glucose in normoglycaemic C57BL/6 (B6) mice. AMG-3969 is highly effective in promoting carbohydrate substrate. AMG-3969 exhibits extended changes to carbohydrate oxidation as observed by increased respiratory exchange ratio into the next night and day after a single dose.