T0901317

Min.Order / FOB Price:Get Latest Price

10 Milligram	Negotiable

10 Milligram

Negotiable

Min.Order :10 Milligram
Purity: ≥98%

Keywords

T0901317 T-0901317 high purity and best price

Quick Details

Appearance:
Application:For laboratory use only- not intended for drug manufacturing, not for household, human or animal consumption
PackAge:
ProductionCapacity:1|Kilogram|Month
Storage:room temperature
Transportation:by air

Superiority:

We are a CRO company, and our Research and Development team is consisted of PhDs and Masters in chemistry and pharmacy.

We are committed to protect our customer’s privacy with the highest level of ethical standard. Our dedicated team will follow up on every order and provide instant feedback on the status to our customer.

We stand behind our product by providing a complete QA report. The test data of customer order can be provided upon request.

We make our efforts to offer customer innovative, customized, high-quality service.

Our custom manufacturing encompasses everything from pharmaceutical intermediates to API.

Details:

T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively, inhibits nuclear factor/κB (NF/κB) target: LXR, FXR; IC 50: 50 nM and 5 μM. In vitro: upregulates the expression and activity of TM, T0901317 treatment inhibits nuclear factor κB (NF/κB) signaling and the secretion of high glucose induced proinflammatory mediators, including tumor necrosis factor α and interleukin 1β in GECs. T0901317 enhances the interaction between LXR α and the transcriptional coactivator, p300, in GEC extracts. In vivo: The reference dose is 10mg/kg/d. You can dilute the product in 0.5% carboxymethylcellulose. Administration of T0901317 does not lead to severe myocardial lipid accumulation in rats despite of its high plasma availability. Administration of T0901317 to high-fat fed rats augments diet-induced hyperlipidemia. T0901317 completely restores glucose transporter 4 expression and insulin-stimulats Akt substrate of 160 kDa phosphorylation in all investigated muscles

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