TIANFU-CHEM - Tolva...

TIANFU-CHEM - Tolvaptan

TIANFU-CHEM - Tolvaptan

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1 Kilogram

FOB Price: USD 1000.0000

  • Min.Order :1 Kilogram
  • Purity: 99.0%
  • Payment Terms : L/C,D/A,D/P,T/T,,MoneyGram,Other

Keywords

Tolvaptan 150683-30-0 C26H25ClN2O3

Quick Details

  • Appearance:Solid
  • Application:Organic synthesis
  • PackAge:IN 25kg drums
  • ProductionCapacity:10|Metric Ton|Month
  • Storage:In Room Temperature
  • Transportation:As per MSDS

Superiority:

Henan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license.

We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the company is to put quality first and put our customer’s needs first - the satisfaction of our customers is the company's ultimate goal.

Improving product quality and service level is our responsibility, and creating more value for our customer’s is our purpose. We are constantly striving to make Henan Tianfu a leading chemical supplier, and hope to create a better future with you.

Details:

Tolvaptan Basic information
Description Synthesis Precautions References
Product Name: Tolvaptan
Synonyms: N-[4-(9-chloro-6-hydroxy-2-azabicyclo[5.4.0]undeca-8,10,12-triene-2-carbonyl)-3-methyl-phenyl]-2-methyl-benzamide;N-[4-[(5R)-7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl]-3-methylphenyl]-2-methylbenzamide;Tolvaptan;OPC 41061;OPC-41061;SaMsca;Tolvaptan Tablets;N-(4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-Methylphenyl)-2-MethylbenzaMide
CAS: 150683-30-0
MF: C26H25ClN2O3
MW: 448.94
EINECS:
Product Categories: APIs;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Isotope Labelled Compounds;Tolvaptan;Samsca;Other APIs;Inhibitors
Mol File: 150683-30-0.mol
Tolvaptan Structure
Tolvaptan Chemical Properties
Melting point 219-222°C
storage temp. Refrigerator
solubility DMSO: ≥15mg/mL
color white to tan
Safety Information
MSDS Information
Tolvaptan Usage And Synthesis
Description Tolvaptan(trade names Samsca and Jinarc) is an oral selective vasopressin antagonist developed by Otsuka for the treatment of hyponatremia, and it is a non-peptide selective antidiuretic hormone receptor antagonist. The drug can increase the concentration of sodium ions in the plasma, and help the excess water discharge from the urine. The drug could enhance the ability of the kidney to deal with water, and significantly reduce the weight and edema of patients while not accompanied by increased electrolyte excretion, without destroying the blood electrolyte balance. The drug can be used to treat hyponatremia caused by congestive heart failure, various edematous diseases, cirrhosis and antidiuretic hormone deficiency syndrome. The study found that, when the plasma sodium concentration decreased, in order to maintain the balance of sodium concentration inside and outside the cell, extracellular fluid will enter the cell, so the cells will swell. When the brain cells swell, it will lead to a variety of hyponatremia symptoms, including dizziness, weakness, headache, nausea, confusion, consciousness and convulsions. Severe hyponatremia can lead to coma and death. There is no corresponding study of tolvaptan tablets in patients with severe hyponatremia.
Synthesis Synthesis of Tolvaptan
Fugure 1: Synthesis of Tolvaptan
Precautions Tolvaptan(SAMSCA) should be initiated and re-initiated in patients only in a hospital where serum sodium can be monitored closely. Too rapid correction of hyponatremia (e.g., >12 mEq/L/24 hours) can cause osmotic demyelination resulting in dysarthria, mutism, dysphagia, lethargy, affective changes, spastic quadriparesis, seizures, coma and death. In susceptible patients, including those with severe malnutrition, alcoholism or advanced liver disease, slower rates of correction may be advisable.
Tolvaptan(SAMSCA) is contraindicated in the following conditions:
 
Urgent need to raise serum sodium acutely
Inability of the patient to sense or appropriately respond to thirst
Hypovolemic hyponatremia
Concomitant use of strong CYP 3A inhibitors
Anuric patients
Hypersensitivity (e.g. anaphylactic shock, rash generalized) to tolvaptan or its components
References #
#
Chemical Properties White Solid
Uses Tolvaptan (OPC-41061) is a selective, competitive arginine vasopressin receptor 2 antagonist with an IC50 of 1.28μM for the inhibition of AVP-induced platelet aggregation. Tolvaptan (OPC-41061) is used to treat hyponatremia (low blood sodium levels) assoc
Uses Labelled Tolvaptan s, and the syndrome of inappropriate antidiuretic hormone (SIADH).
Uses It is a selective, competitive arginine vasopressin V2 receptor antagonist f inappropriate antidiuretic hormone (SIADH).
Tolvaptan Preparation Products And Raw materials

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