High quality in stock CAS NO.936091-26-8

High quality in stock CAS NO.936091-26-8

Min.Order / FOB Price:Get Latest Price

1 Kilogram	FOB Price:USD 1.0000 -3.0000

1 Kilogram

FOB Price:USD 1.0000 -3.0000

Min.Order :1 Kilogram
Purity: 99%
Payment Terms : T/T,,MoneyGram,Other

Keywords

936091-26-8 936091-26-8 TG 101348SAR302503 TG 101348SAR302503

Quick Details

Appearance:crystal, powder
Application:Pharmaceutical intermediates
PackAge:as your request
ProductionCapacity:10|Kilogram|Day
Storage:stay in dry, cool and well-sealed
Transportation:EMS,HK EMS,FEDEX,DHL,TNT

Superiority:

ProName: Cycloheptane-1,3-Dione
CasNo: 1194-18-9
Molecular Formula: C7H10O2
Appearance: Look at the detailed information
Application: intermediates
DeliveryTime: according to the clients requirement
PackAge: according to the clients requirement
Port: China Main Port
ProductionCapacity: 100 Metric Ton/Year
Purity: 95%, 99%
Storage: According to the characteristics of th...
Transportation: by sea or air
LimitNum: 100 Gram

Details:

TG101348 (SAR302503) is an orally available inhibitor of Janus kinase 2 (JAK-2) developed for the treatment of patients with myeloproliferative diseases including myelofibrosis. TG101348 acts as a competitive inhibitor of protein kinase JAK-2 with IC50=6 nM; related kinases FLT3 and RET are also sensitive, with IC50=25 nM and IC50=17 nM, respectively. Significantly less activity was observed against other tyrosine kinases including JAK3 (IC50=169 nM).[1] In treated cells the inhibitor blocks downstream cellular signalling (JAK-STAT) leading to suppression of proliferation and induction of apoptosis.

Myelofibrosis is a myeloid malignancy associated with anemia, splenomegaly, and constitutional symptoms. Patients with myelofibrosis frequently harbor JAK-STAT activating mutations that are sensitive to TG101348. Phase I trial results focused on safety and efficacy of TG101348 in patients with high- or intermediate-risk primary or post–polycythemia vera/essential thrombocythemia myelofibrosis have been published in 2011.

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