- Min.Order :1 Gram
- Purity: 99%
- Payment Terms : L/C,T/T,
Keywords
ANISOMYCIN high purity ANISOMYCIN factory supply ANISOMYCIN
Quick Details
- Appearance:Crystalline
- Application:Used in a base-free iridium-catalyzed direct alkylation of active methylene compounds with alcohols.1
- PackAge:as you requested
- ProductionCapacity:10|Kilogram|Day
- Storage:room temperature
- Transportation:by courier
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1.Noble Metal Catalysts (Pt.Pd...)
2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...)
3.OLED intermediates (Fluorene,Carbazole,Boric acid...)
4.Customs Synthesis
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Details:
| CAS: | 22862-76-6 |
| MF: | C14H19NO4 |
| MW: | 265.3 |
| EINECS: | 245-269-7 |
| Product Categories: | Antibiotics;Protein Kinase;antibiotic |
| Mol File: | 22862-76-6.mol |
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| ANISOMYCIN Chemical Properties |
| Melting point | 140-141 C |
| alpha | D23 -30° (methanol) |
| Fp | 87℃ |
| storage temp. | 2-8°C |
| solubility | methanol: 20 mg/mL, clear, colorless to faintly yellow |
| form | solid |
| pka | 7.9(at 25℃) |
| color | white |
| Water Solubility | Soluble in water at 2 mg/ml, in DMSO at 20mg/ml, and in methanol at 20mg/ml |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| Safety Information |
| Hazard Codes | T,Xn |
| Risk Statements | 25-36/37/38-20/21/22 |
| Safety Statements | 45-36-26 |
| RIDADR | UN 3462 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | BZ9800000 |
| F | 3-10 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| ANISOMYCIN Usage And Synthesis |
| Chemical Properties | Crystalline |
| Uses | Anisomycin is a phenylmethylenepyrrolidine first isolated from Streptomyces griseolus in 1954 as an antiprotozoan with antifungal activity. Anisomycin is an inhibitor of protein synthesis by binding to the 60S ribosomal subunit. Interestingly, anisomycin has found use for the induction of amnesia in animal models. More recently, anisomycin has been demonstrated to induce apoptosis, to be a selective signalling agonist, to activate mitogen-activated protein (MAP) kinases and to be immunomodulatory via its action on T cells. |
| Definition | ChEBI: An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system. |
| Biological Activity | Protein synthesis inhibitor (blocks translation). Potent activator of stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase. Acts as a potent signaling agonist to selectively elicit homologous desensitization of immediate early gene induction (c-fos, fosB, c-jun, junB and junD). |
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