TIANFU CHEM Furazolidone

Details:

Furazolidone Basic information
Antibacterials Aquaculture Fungicides Chemical Properties Uses Production methods
Product Name: Furazolidone
Synonyms: 2-Furanmethanimine, 5-nitro-N-(2-oxo-3-oxazolidinyl)-;2-Oxazolidinone, 3-((5-nitrofurfurylidene)amino)-;2-Oxazolidinone, 3-((5-nitrofurfurylidine)amino)-;2-Oxazolidinone, 3-[[(5-nitro-2-furanyl)methylene]amino]-;2-Oxazolidinone,3-[[(5-nitro-2-furanyl)methylene]amino]-;3-(((5-nitro-2-furanyl)methylene)amino)-2-oxazolidinon;3-(((5-Nitro-2-furanyl)methylene)amino)-2-oxazolidinone;Furaxon
CAS: 67-45-8
MF: C8H7N3O5
MW: 225.16
EINECS: 200-653-3
Product Categories: Active Pharmaceutical Ingredients;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical intermediate;FUROXONE;Pharmaceutical intermediates
Mol File: 67-45-8.mol
Furazolidone Structure
Furazolidone Chemical Properties
Melting point  254-256°C (dec.)
Fp  2 °C
storage temp.  0-6°C
solubility  formic acid: soluble50mg/mL
color  yellow
Sensitive  Light Sensitive
Merck  13,4321
Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
NIST Chemistry Reference Furazolidone(67-45-8)
EPA Substance Registry System 2-Oxazolidinone, 3-[[(5-nitro-2-furanyl)methylene] amino]-(67-45-8)
Safety Information
Hazard Codes  Xn,F
Risk Statements  62-40-36-20/21/22-11-68
Safety Statements  36-22-36/37-16
WGK Germany  3
RTECS  RQ3675000
TSCA  Yes
HS Code  29349990
Hazardous Substances Data 67-45-8(Hazardous Substances Data)

Furazolidone Usage And Synthesis
Antibacterials Furazolidone is a kind of nitrofuran-class antibacterial agents which has certain antibacterial effects on gram positive and negative bacteria including Salmonella, Shigella, Escherichia coli, Klebsiella pneumoniae Peter, Enterobacter spp., Staphylococcus aureus, Enterococcus faecalis, Streptococcus pyogenes, Vibrio cholerae, Campylobacter, Bacteroides spp. It also has antibacterial activities against Trichomonas, Giardia lamblia at certain concentration. Its mechanism of action is by interfering with the bacterial oxidoreductase and thereby blocking the normal metabolism of bacteria. It is mainly used for treatment of various intestinal infections, dysentery, diarrhea, enteritis, Escherichia coli septicemia, typhoid, cholera, infectious rhinitis, blackhead, trichomoniasis, coccidiosis and Cartesian WBC. It can also be combined together with other drugs such as antacids for treatment of Helicobacter pylori-induced inflammation.
Furazolidone has side effects on infants, such as liver and kidney damage, allergic reactions, etc., Thereby, it is generally recommended to minimize the use or avoid using on infants.
Aquaculture Fungicides Furazolidone has a low toxicity to fish, turtles etc. It can be used for both prevention as well as treatment of early stage disease in the field of freshwater fish farming. Upon the water temperature being lower than 20 °C, rinse 20 to 30 minutes; at a temperature being higher than 20 °C, rinse 10 to 15 minutes. At the water temperature being close to 20 °C, Furazolidone, at a concentration of 0.025 ppm, can inhibit a variety of pathogens. For comparison, in the pool, tank-bred goldfish, or tropical fish can tolerate a concentration of 1.5ppm without die. Therefore, in case of serious illness, you can even use a concentration in the range of 0.4~1.0ppm; After sprinkling over the entire pool with the drugs, domestic fish should be more fed high-quality commercialized feed; ornamental fish must be fed with live animal foodstuffs such as live Daphnia, Cyclops, chironomid larvae, and tubificidae; improve the nutrients conditions of diseased fish and enhance their capability of disease resistance. For prevention of various kinds of disease of domestic fish such as bald white mouth disease, gill disease, stigmatosis, leprnorthsis, red skin disease, immerse and rinse one time before stocking; For prevention of diseases of ornamental fish such as bald white mouth disease, gill rot, leprnorthsis, and destroyed fin and tail, etc. For fish fed in a small body of water, immerse once a day, and rinse once again at the interval of one day. Treatment of various diseases of ornamental fish such as bald white mouth disease, gill rot, leprnorthsis, and destroyed fin and tail, immerse and rinse once daily, and rinse once again at the interval of one day; it can be continuously rinsed 3 to 5 times until the disappearance of symptoms and the recovery of the fish.
Furazolidone residue will cause potential harm to humans, causing hemolytic anemia, multiple neuritis, eye damage and acute hepatic necrosis. Thereby it has been disabled in Chinese, EU and some other countries.
The above information is edited by the Chemicalbook of Dai Xiongfeng.
Chemical Properties It is light yellow crystalline powder which is odorless and has a bitter taste. Its melting point is 275 °C (decomposition). It is insoluble in water and ethanol, slightly soluble in chloroform, slightly soluble in dimethylformamide. Mice: orally administration, LD501.5-4.54g/kg.