NewblueCHEM--1492-18-8--High purity Calcium folinate factory price

NewblueCHEM--1492-18-8--High purity Calcium folinate factory price

Min.Order / FOB Price:Get Latest Price

1 Metric Ton	FOB Price: USD 2000.0000

1 Metric Ton

FOB Price: USD 2000.0000

Min.Order :1 Metric Ton
Purity: 99%
Payment Terms : L/C,T/T

Keywords

TIANFUCHEM--1492-18-8 High purity Calcium folinate Calcium folinate factory price

Quick Details

Appearance:White Powder
Application:API，Pharmaceutical intermediates
PackAge:25KGS/Drum
ProductionCapacity:1000|Metric Ton|Day
Storage:Room temperature
Transportation:BY SEA

Superiority:

NewblueCHEM--1492-18-8--High purity Calcium folinate factory price

Our company was built in 2009 with an ISO certificate.In the past 10 years,

we have grown up as a famous fine chemicals supplier in China

And we had established stable business

relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.

Our main business covers the fields below:

1.Noble Metal Catalysts (Pt.Pd...)

2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...)

3.OLED intermediates (Fluorene,Carbazole,Boric acid...)

4.Pharmaceutical intermediates

About us

1.More than 10 years chemical exporting experience

We have produced chemical more than fifteen years., 80% products are for export .

More than 10 years chemical exporting experience. Good and stabilized factory price.

2.Strict quality control system

3.Supply sample

Before order , we can send the sample for your testing . We ensure the quality is the same as bulk quantity .

Our advantage:

Q1:Can I get the free sample

A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.

Q2: How to start orders or make payments

A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information.

Payment by T/T, or Paypal or L/C.

Q3: How to confirm the Product Quality before placing orders

A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.

You can send us your product specifications and requests,we will manufacture the products according to your requests.

Q4:What’s your MOQ

A:Usually according you demand.

Q5: How about delivery leadtime

A:Delivery lead time: As soon as possible. (Chinese holiday not included)

Q6:Is there a discount

A:Different quantity has different discount.

Q7: How to contact us

A:You can chat with us by Trademanager,Email,WhatsAPP,Wechat.

You can choose your interested products and send inquiry to us.

You can dial our telephone directly, you will get our reply.

Details:

NewblueCHEM--1492-18-8--High purity Calcium folinate factory price

Our company was built in 2009 with an ISO certificate.In the past 10 years,

we have grown up as a famous fine chemicals supplier in China

And we had established stable business

relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.

Details

Calcium folinate

English Synonyms: Folinic acid calcium salt; FOLINIC ACID, CALCIUM SALT UPS28; Calcium folinate, Leucovorine calcium; Folinic acid calcium salt> 97.5%; Calcium Folinate Hydrate; Calcium Leucoverin; 5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt, 5-HCO-H4PteGlu, Calcium folinate, Citrovorum factor calcium salt, Leucovorin calcium salt, 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium salt; Folinic acid hydrate calcium salt

CAS number: 1492-18-8

Molecular formula: C20H21CaN7O7

Molecular weight: 511.5

EINECS No. 216-082-8

Related Categories: APIs; Antitumors for Research and Experimental Use; Biochemistry; API's; Research Reagents; Nutritional Studies; WELLCOVERIN; Antineoplastic Agents and Immunosuppressants; Plant Biochemical Extracts; Vitamins; Intermediates; APIs for APIs; Body; Small molecule inhibitors; Pharmaceutical raw materials

Mol file: 1492-18-8.mol

Leucovorin

Leucovorin properties

Form powder

CAS Database 1492-18-8 (CAS DataBase Reference)

Calcium folinate use and synthesis method

Folic acid antagonist antidote Calcium leucovorin folic acid antagonist drugs is also antidote, also known as Ca folium, melo folate, aldehyde folate calcium, acetic acid, calcium valerate, leucovorin, at room temperature Yellowish white to yellow crystalline or amorphous powder, odorless. Soluble in water, almost insoluble in ethanol or ether, soluble in sodium hydroxide solution. Calcium leucovorin is a folic acid-reduced formylated derivative that acts like folic acid and is the active form of folic acid in the body. Into the human body, through the tetrahydrofolate reductase into tetrahydrofolate, can effectively combat methotrexate-induced toxicity. Calcium leucovorin has the "rescue" toxic effects of folic acid antagonists in vivo, is conducive to thymine nucleotide, DNA, RNA and protein synthesis, can stimulate leukocyte growth and maturation. This product can limit the extent of damage methotrexate on normal cells, through mutual competition, and can reverse methotrexate on bone marrow and gastrointestinal mucosal response, but there is no effect on the methotrexate neurotoxicity . Mainly used as folic acid antagonists (such as methotrexate, methotrexate, phenytoin, phenobarbital, pyrimethamine or trimethoprim, etc.) antidote. When oral folic acid poor efficacy, for stomatitis, malnutrition, gestational or infancy-induced megaloblastic anemia and leucopenia. However, vitamin B12 deficiency anemia does not apply.

In recent years, the application of leucovorin as colon, rectal cancer adjuvant therapy, combined with the use of fluorouracil, prolong survival.

Intramuscular injection:

(1) moderate anti-folate metabolism drugs, 1 6 ~ 12mg, once every 6 hours, a total of 4 times.

(2) Megaloblastic anemia: 1mg on the 1st, 1st on the 1st.

(3) leukopenia: each 3 ~ 6mg, 1 day. Intravenous drip: Anti-folic acid metabolism drug poisoning: 75mg drip completed within 12 hours, then changed to intramuscular injection. Adverse reactions are rare, occasionally rash, hives or asthma and other allergic reactions. Aciduria (pH <7), ascites, dehydration, gastrointestinal obstruction, pleural effusion or renal dysfunction in patients with caution.

Calcium leucovorin oral absorption, 1.72h ± 0.8h serum reduced folic acid peak; intramuscular injection 0.71h ± 0.09h peak. Serum folic acid folic acid t1 / 2 after intramuscular injection of 3.5h. Whether oral or intramuscular injection can be maintained 3 ~ 6h. The role of the liver and intestinal mucosa metabolism of 5-methyltetrahydrofolate, oral more than intramuscular injection of metabolism. 80% to 90% of renal excretion, a small amount of discharge with the feces.

Our main business covers the fields below:

1.Noble Metal Catalysts (Pt.Pd...)

2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...)

3.OLED intermediates (Fluorene,Carbazole,Boric acid...)

4.Pharmaceutical intermediates

Packing:

About us

1.More than 10 years chemical exporting experience

We have produced chemical more than fifteen years., 80% products are for export .

More than 10 years chemical exporting experience. Good and stabilized factory price.

2.Strict quality control system

3.Supply sample

Before order , we can send the sample for your testing . We ensure the quality is the same as bulk quantity .

Delivery:

Our advantage:

Q1:Can I get the free sample

A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.

Q2: How to start orders or make payments

A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information.

Payment by T/T, or Paypal or L/C.

Q3: How to confirm the Product Quality before placing orders

A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.

You can send us your product specifications and requests,we will manufacture the products according to your requests.

Q4:What’s your MOQ

A:Usually according you demand.

Q5: How about delivery leadtime

A:Delivery lead time: As soon as possible. (Chinese holiday not included)

Q6:Is there a discount

A:Different quantity has different discount.

Q7: How to contact us

A:You can chat with us by Trademanager,Email,WhatsAPP,Wechat.

You can choose your interested products and send inquiry to us.

You can dial our telephone directly, you will get our reply.

Our Factory

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