(+)-Camptothecin

Details:

• Molecular Formula: C₂₀H₁₆N₂O₄
• Form: Solid
• Solubility: Soluble in chloroform/methanol (4:1) (4 mg/ml), DMSO (10 mg/ml), methanol (40 mg/ml), 0.1N sodium hydroxide (50 mg/ml), and acetic acid. Insoluble in water.
• Melting Point: 260 °C (lit.)(dec.)
• Boling Point: 757.01 °C at 760 mmHg
• Flash Point: 411.63 °C
• Density: 1.51 g/cm³
• Refractive Index: n²⁰_D 1.75

• Safety

  • UN Number: UN 1544, Class 6.1, Packing group III
  • RTECS: UQ0492000
• Camptothecin was originally isolated from the stem wood of the Camptotheca acuminata tree and was shown to exhibit antileukemic/antitumour activity, and reversibly inhibit nuclear Topo I (topoisomerase I) by binding to and stabilizing the topoisomerase-DNA covalent complex. Advancing replication forks are believed to interact with these complexes leading to double strand breaks, which is thought to be responsible for much of the cytotoxicity; other research has shown that some of the antitumor activity could be derived from the inhibition of NOS2 (iNOS or inducible nitric oxide synthase) which generates nitric oxide, an important regulator of angiogenesis and other biochemical pathways. The discovery of Camptothecin spurred the development of many derivatives with superior activity and solubility, including Irinotecan (we offer this too) and Topotecan (we offer this too). Although most noted for its anticancer activity, Camptothecin and derivatives have shown other pertinent biochemical actions, including: antiprotozoal, antimalarial, inhibition of HIV, upregulation of p53, and induction of apoptosis. This product also exhibits intense blue fluorescence when exposed to UV light, which could be useful in optical experiments